Understanding the chemistry of key intermediates is fundamental for success in organic synthesis. 3,5-Bis(trifluoromethyl)benzaldehyde (CAS 401-95-6) is a prime example of such a molecule, valued for its unique structure and broad applicability in industries ranging from pharmaceuticals to agrochemicals. As a manufacturer and supplier, we are dedicated to providing high-quality 3,5-Bis(trifluoromethyl)benzaldehyde and sharing insights into its chemical nature and synthetic utility.

Chemical Properties and Reactivity

3,5-Bis(trifluoromethyl)benzaldehyde is an aromatic aldehyde characterized by the presence of two trifluoromethyl (-CF3) groups at the meta positions of the benzene ring relative to the aldehyde group. These highly electronegative groups exert a significant electron-withdrawing effect on the aromatic system. This electronic influence enhances the electrophilicity of the carbonyl carbon, making the aldehyde group more reactive towards nucleophilic attack. Furthermore, the electron-deficient aromatic ring is more susceptible to nucleophilic aromatic substitution reactions under specific conditions, though electrophilic aromatic substitution is generally deactivated.

Key physical properties typically include:

  • Appearance: Colorless to pale yellow liquid.
  • Purity: Often available at ≥99.0% GC purity, essential for precise synthesis.
  • Molecular Formula: C9H4F6O.
  • Molecular Weight: Approximately 242.12 g/mol.
  • Solubility: Generally insoluble in water but soluble in many organic solvents.

The boiling point is reported around 37°C at 1.3 mm Hg, indicating a relatively volatile compound.

Synthesis and Sourcing Considerations

While specific synthesis pathways can vary, 3,5-Bis(trifluoromethyl)benzaldehyde is typically prepared through established organic transformations. For industrial-scale production, efficient and cost-effective routes are employed to ensure a stable supply. When considering where to buy this compound, it is crucial to look for manufacturers who can guarantee high purity and consistent quality. Factors like packaging (often in drums for bulk purchases) and storage conditions (cool, ventilated, and protected from light) are also important for maintaining product integrity.

Applications Across Industries

The versatility of 3,5-Bis(trifluoromethyl)benzaldehyde stems from its ability to serve as a building block for complex molecules, finding extensive use in:

  • Pharmaceuticals: As an intermediate in the synthesis of APIs, where the trifluoromethyl groups contribute to enhanced bioavailability and metabolic stability of drug candidates.
  • Agrochemicals: In the creation of advanced pesticides and herbicides, improving their efficacy and environmental persistence.
  • Materials Science: For developing specialized fluorinated polymers and electronic materials with unique properties.

We are a leading supplier of 3,5-Bis(trifluoromethyl)benzaldehyde in China, committed to providing our clients with top-tier products at competitive prices. For your next synthesis project, consider us your trusted source for this vital intermediate. Contact us to obtain a quote and discuss your specific needs.