Understanding the fundamental chemistry of crucial intermediates is vital for researchers and procurement specialists alike. 4-Bromo-2-fluorophenol, identified by CAS number 2105-94-4, is a prime example of such a compound, highly valued for its role in sophisticated organic synthesis, particularly within the pharmaceutical and agrochemical sectors. This article explores its key chemical properties, typical synthesis pathways, and the quality assurance measures employed by leading manufacturers.

The molecular structure of 4-Bromo-2-fluorophenol (C6H4BrFO) features a benzene ring substituted with a hydroxyl group, a bromine atom at the para position, and a fluorine atom at the ortho position relative to the hydroxyl. This arrangement imparts unique electronic and steric properties, making it a versatile starting material. If you are looking to buy 4-Bromo-2-fluorophenol, understanding these aspects will aid in your selection of a reliable supplier.

Key Chemical Properties and Specifications

4-Bromo-2-fluorophenol typically presents as a clear, colorless to brownish liquid. Its molecular weight is approximately 191.00 g/mol. Purity levels are critical, with most applications demanding ≥98% purity, often verified by GC analysis. The compound's boiling point is around 79 °C at 7 mmHg, and its density is approximately 1.744 g/mL at 25 °C. These physical properties are essential for handling, storage, and reaction optimization. As a dedicated manufacturer, we ensure these specifications are consistently met.

Synthesis Routes for 4-Bromo-2-fluorophenol

The synthesis of 4-Bromo-2-fluorophenol commonly involves the electrophilic bromination of 2-fluorophenol. A typical route might entail dissolving 2-fluorophenol in a suitable solvent, such as dichloromethane, and then slowly adding bromine while maintaining a controlled low temperature. Subsequent quenching with a reducing agent like sodium bisulfite, followed by separation of the organic layer and evaporation of the solvent, yields the desired product. This process requires careful control of reaction conditions to achieve high yields and purity. Accessing this material from an experienced supplier in China means benefiting from established and optimized production methods.

Quality Assurance from a Reputable Manufacturer

For demanding applications, particularly in the pharmaceutical industry, the quality and consistency of 4-Bromo-2-fluorophenol are non-negotiable. Leading manufacturers employ rigorous quality control measures throughout the production process. This includes raw material verification, in-process monitoring, and final product testing using advanced analytical techniques. Certificates of Analysis (CoA) are essential documents that provide detailed information on the product's quality parameters. We are committed to providing this level of assurance, ensuring that when you purchase our product, you receive material of the highest standard.

Applications and Procurement Considerations

Beyond its role in pharmaceuticals and agrochemicals, 4-Bromo-2-fluorophenol is also utilized in materials science and as a reagent in organic synthesis research. When procuring this intermediate, consider the supplier's ability to provide technical support, their adherence to safety regulations, and their overall commitment to customer satisfaction. We offer competitive prices and a reliable supply chain for your needs.

In summary, 4-Bromo-2-fluorophenol (CAS 2105-94-4) is a key intermediate with a well-defined chemical profile and crucial applications. Understanding its properties and synthesis, and partnering with a quality-focused manufacturer, ensures that you can effectively leverage this compound in your research and production. We are your trusted source for this essential building block.