4-Ethynylbenzaldehyde (CAS 63697-96-1) is a molecule that commands attention in the realm of organic chemistry due to its distinctive combination of functional groups. At NINGBO INNO PHARMCHEM CO.,LTD, we harness the unique reactivity of this compound to drive innovation in pharmaceutical intermediates and beyond. Understanding its chemical behavior is key to unlocking its full potential.

The presence of both an aldehyde (–CHO) and a terminal alkyne (–C≡CH) on the same aromatic ring makes 4-ethynylbenzaldehyde a highly versatile synthon. The aldehyde group readily participates in nucleophilic addition reactions, condensation reactions (like Knoevenagel or aldol condensations), and oxidation/reduction processes. Simultaneously, the terminal alkyne can undergo a variety of transformations, including Sonogashira coupling, click chemistry (copper-catalyzed azide-alkyne cycloaddition), and metal-catalyzed additions. This dual reactivity allows for sequential or concurrent functionalization, enabling the efficient construction of complex molecular architectures. The accurate p-ethynylbenzaldehyde molecular formula (C9H6O) and its physical properties such as melting point guide our chemists in optimizing these reaction conditions.

NINGBO INNO PHARMCHEM CO.,LTD utilizes these properties extensively. For instance, in pharmaceutical synthesis, we might employ the aldehyde for forming amide linkages via reductive amination, while simultaneously using the alkyne for a Sonogashira coupling to attach a complex aryl group. The purity of the 4-ethynylbenzaldehyde we supply is critical for the success of these multi-step processes. Knowing the benzaldehyde, 4-ethynyl- boiling point also aids in purification steps, ensuring the removal of any byproducts or unreacted starting materials.

Beyond pharmaceuticals, the reactivity of 4-ethynylbenzaldehyde makes it valuable for materials science. The alkyne group can be used for polymerization or as a reactive handle for surface functionalization. The aldehyde can serve as a point for attaching pendant groups to polymer chains, tailoring the material's properties. This versatility underscores why 4-acetylenylbenzaldehyde is a sought-after intermediate. NINGBO INNO PHARMCHEM CO.,LTD is adept at producing this compound to meet the exacting specifications required for these advanced applications.

In conclusion, the intrinsic chemical reactivity of 4-ethynylbenzaldehyde (CAS 63697-96-1) is a significant asset in organic synthesis. NINGBO INNO PHARMCHEM CO.,LTD leverages this reactivity, combined with our commitment to quality and expertise, to provide essential building blocks for the pharmaceutical and chemical industries, driving forward the creation of innovative molecules.