5-Fluoropyridine-2-carbonitrile, identified by its CAS number 327056-62-2, is a fascinating molecule with significant utility in the fine chemical sector. Its structure, a pyridine ring substituted with a fluorine atom and a nitrile group, imbues it with unique chemical properties that make it an indispensable intermediate in various synthetic pathways, particularly for pharmaceuticals and agrochemicals. This article delves into its synthesis, key chemical characteristics, and the broad spectrum of its applications.

Chemically, 5-Fluoropyridine-2-carbonitrile (molecular formula C6H3FN2, molecular weight 122.10) exhibits properties typical of both fluorinated aromatics and nitriles. Its melting point typically falls between 35-41°C, and it often appears as a white to almost white powder or crystalline solid. The presence of the electron-withdrawing fluorine and nitrile groups influences the reactivity of the pyridine ring, making it susceptible to nucleophilic aromatic substitution under specific conditions and activating positions for electrophilic attack. The nitrile group itself is a versatile functional handle, readily convertible into other important functional groups like carboxylic acids, amides, amines, and tetrazoles through well-established chemical transformations.

While multiple synthetic routes exist, one common approach involves the fluorination of a pyridine precursor. For instance, diazotization of 2-cyano-5-aminopyridine followed by thermal decomposition, often using fluoroboric acid as a fluorinating agent, can yield 5-Fluoropyridine-2-carbonitrile with a respectable yield. This method is appreciated for its operational simplicity and practicality, making it suitable for industrial scale-up. As a leading manufacturer, we employ optimized synthesis protocols to ensure consistent production of high-purity material.

The applications of 5-Fluoropyridine-2-carbonitrile are diverse and impactful. In the pharmaceutical industry, it serves as a crucial intermediate for synthesizing numerous APIs, contributing to the development of drugs targeting various therapeutic areas. Its structure is a favored motif for enhancing drug potency, stability, and pharmacokinetic profiles. In agrochemistry, it is a vital building block for creating advanced herbicides, insecticides, and fungicides, playing a role in enhancing crop yields and protection. Researchers also find it valuable in material science and as a general fine chemical intermediate for custom synthesis projects.

For businesses seeking to purchase 5-Fluoropyridine-2-carbonitrile, partnering with a reputable China-based manufacturer like us offers significant advantages. We guarantee a purity of ≥98.0% and provide comprehensive support for bulk supply and contract manufacturing. We invite you to explore the synthetic potential of this versatile compound. Contact us for detailed product specifications, pricing, and to discuss how we can fulfill your specific chemical intermediate requirements.