The Chemistry of Chloramphenicol: Understanding a Key Intermediate
Chloramphenicol, an antibiotic known for its broad spectrum of activity, has been a cornerstone in treating bacterial infections for decades. The synthesis of this vital pharmaceutical is a complex chemical process, and at its heart lies a critical intermediate: (1S,2S)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol (CAS: 2964-48-9). Understanding the properties and sourcing of this compound is key for any entity involved in its production or related research. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated manufacturer, offers insights into this important chemical.
The molecular structure of (1S,2S)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is characterized by a para-substituted nitrophenyl group attached to a propanediol backbone with an amino group at the second carbon. This specific stereochemical configuration, denoted by (1S,2S), is crucial for its subsequent conversion into Chloramphenicol. The presence of the nitro group also plays a significant role in the reactivity and synthetic utility of the molecule.
Manufacturers strive to produce this intermediate with exceptional purity, often exceeding 98.0%. The appearance is typically described as a white to yellow crystalline powder, a visual indicator that, along with analytical data, confirms product quality. For pharmaceutical synthesis, impurities in intermediates can lead to byproducts that are difficult to remove and can compromise the safety and efficacy of the final API. Therefore, sourcing from a reliable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD., who adheres to stringent quality control measures, is paramount.
When procurement specialists are tasked with buying (1S,2S)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol, they will invariably look for competitive pricing and a stable supply chain. The price of CAS 2964-48-9 can vary based on market demand, production scale, and supplier location. As a Chinese manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. offers the advantage of efficient production and competitive pricing, especially for bulk orders, making us an ideal partner for pharmaceutical companies and contract manufacturers globally.
In essence, the journey from basic chemical intermediate to a life-saving antibiotic like Chloramphenicol relies heavily on the quality and availability of compounds like (1S,2S)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol. We encourage R&D scientists and purchasing managers to consider NINGBO INNO PHARMCHEM CO.,LTD. as their trusted supplier. Reach out to us to inquire about purchasing this essential chemical and to learn more about our manufacturing capabilities and commitment to excellence in the pharmaceutical intermediate sector.
Perspectives & Insights
Chem Catalyst Pro
“This specific stereochemical configuration, denoted by (1S,2S), is crucial for its subsequent conversion into Chloramphenicol.”
Agile Thinker 7
“The presence of the nitro group also plays a significant role in the reactivity and synthetic utility of the molecule.”
Logic Spark 24
“Manufacturers strive to produce this intermediate with exceptional purity, often exceeding 98.”