In the intricate world of pharmaceutical manufacturing and organic synthesis, the quality and availability of key intermediates are paramount. One such compound that plays a crucial role is 3-Chloro-5-hydroxybenzonitrile, identified by CAS number 473923-97-6. This chemical, often sought by procurement managers and research scientists, serves as a vital building block for numerous complex molecules, particularly within the pharmaceutical sector.

Understanding 3-Chloro-5-hydroxybenzonitrile

3-Chloro-5-hydroxybenzonitrile is characterized by its physical properties, typically appearing as a white to almost white crystalline solid. Its chemical structure, featuring a benzonitrile core with chloro and hydroxyl substituents, lends itself to a variety of synthetic transformations. The compound's melting point is generally reported in the range of 168-172 °C, indicating a stable solid form suitable for handling and storage. Its chemical formula, C7H4ClNO, and molecular weight of approximately 153.57 g/mol are standard data points for chemists and purchasing specialists when evaluating materials.

Key Applications in Pharmaceutical Development

The primary utility of 3-Chloro-5-hydroxybenzonitrile lies in its application as a pharmaceutical intermediate. It is particularly noted for its use in the synthesis of advanced drug candidates. For instance, it is a critical component in the preparation of Doravirine, a non-nucleoside reverse transcriptase inhibitor used in the treatment of HIV. The demand for high-purity intermediates like this is driven by the constant need for effective and safe pharmaceuticals. Researchers seeking to buy this compound often do so for its potential to be transformed into novel therapeutic agents, making it a hot commodity in the chemical sourcing market.

Why Source from Manufacturers in China?

For procurement professionals and R&D teams, sourcing chemical intermediates often involves a strategic decision regarding geographical location and supplier reliability. China has emerged as a global hub for chemical manufacturing, offering competitive pricing and a vast production capacity. When looking to purchase 3-Chloro-5-hydroxybenzonitrile, partnering with a reputable Chinese manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to high-quality material at competitive prices. Our commitment as a dedicated supplier means we understand the stringent requirements of the pharmaceutical industry, providing consistent purity and reliable delivery schedules.

Procurement Considerations

When procuring 3-Chloro-5-hydroxybenzonitrile, several factors are important for B2B buyers. These include the assay or purity level (typically ≥98.0%), the form of the product (powder to crystal), and the packaging options available (e.g., 25 kg drums). Availability from multiple suppliers also indicates market maturity and potential for price negotiation. Understanding the synthesis routes and potential applications, such as its use in creating pyrazole derivatives, is crucial for R&D scientists assessing its suitability for their projects. For those needing to buy this intermediate, seeking quotes from established manufacturers in China is a prudent first step.

In conclusion, 3-Chloro-5-hydroxybenzonitrile is a cornerstone intermediate for many pharmaceutical R&D initiatives. Its availability, purity, and cost-effectiveness are critical for drug development pipelines. By choosing a reliable manufacturer and supplier, businesses can ensure the success of their synthesis projects and contribute to the advancement of healthcare.