The Critical Role of Boc-Ser(Bzl)-OH in Modern Peptide Synthesis
In the intricate world of peptide synthesis, the selection of high-quality building blocks is paramount to achieving successful outcomes. Among these essential components, protected amino acids play a pivotal role, and N-Boc-O-benzyl-L-serine stands out as a particularly valuable reagent. Known by its CAS number 23680-31-1, this derivative of L-serine offers unique advantages for chemists and researchers engaged in complex molecular construction.
N-Boc-O-benzyl-L-serine, often abbreviated as Boc-Ser(Bzl)-OH, features two critical protecting groups: the tert-butyloxycarbonyl (Boc) group on the alpha-amino function and the benzyl (Bzl) group on the side-chain hydroxyl. These protective moieties are strategically employed to prevent unwanted side reactions during peptide chain elongation. The Boc group ensures that the alpha-amino group remains unreactive until it is intentionally deprotected, typically under mild acidic conditions. Concurrently, the benzyl ether protects the serine side chain's hydroxyl group, which can be cleaved later via hydrogenolysis or other suitable methods, allowing for further functionalization or direct incorporation into the final peptide structure.
The utility of Boc-Ser(Bzl)-OH in peptide synthesis is vast. It is a fundamental ingredient for researchers aiming to buy amino acids for solid-phase peptide synthesis (SPPS) or solution-phase synthesis. Its inclusion in peptide sequences can influence the final peptide's hydrophilicity and its ability to interact with biological targets, as serine residues are known to participate in hydrogen bonding. This makes Boc-Ser(Bzl)-OH a key intermediate for manufacturers and suppliers focusing on high-purity amino acid derivatives for the pharmaceutical and biotechnology industries.
Beyond its primary role in peptide assembly, this versatile compound finds applications in broader medicinal chemistry and drug development. Its predictable reactivity and deprotection characteristics make it an attractive building block for synthesizing peptide-based therapeutics, diagnostic agents, and research tools. Researchers exploring novel drug candidates or investigating biological pathways often seek reliable sources for Boc-Ser(Bzl)-OH to ensure the consistency and purity of their synthesized molecules. As a leading N-Boc-O-benzyl-L-serine supplier, NINGBO INNO PHARMCHEM understands these demands and provides materials that meet stringent quality standards.
For procurement, searching for ‘buy N-Boc-O-benzyl-L-serine online’ or ‘N-Boc-O-benzyl-L-serine supplier China’ will lead you to reputable manufacturers. Sourcing high-quality CAS 23680-31-1 from a trusted manufacturer like NINGBO INNO PHARMCHEM ensures that your projects benefit from the compound's exceptional purity and reliable supply chain. Investing in quality intermediates is crucial for the success of research and development, particularly when aiming for novel therapeutics or advanced biological probes.
Perspectives & Insights
Silicon Analyst 88
“Known by its CAS number 23680-31-1, this derivative of L-serine offers unique advantages for chemists and researchers engaged in complex molecular construction.”
Quantum Seeker Pro
“N-Boc-O-benzyl-L-serine, often abbreviated as Boc-Ser(Bzl)-OH, features two critical protecting groups: the tert-butyloxycarbonyl (Boc) group on the alpha-amino function and the benzyl (Bzl) group on the side-chain hydroxyl.”
Bio Reader 7
“These protective moieties are strategically employed to prevent unwanted side reactions during peptide chain elongation.”