In the intricate world of pharmaceutical manufacturing, the quality and availability of specific chemical intermediates are paramount. One such compound that plays a significant role is 2-(2-Chloroethoxy)ethanol, identified by its CAS number 628-89-7. This versatile chemical serves as a foundational building block for a variety of essential medicines, highlighting the importance of reliable sourcing and stringent quality control.

Understanding 2-(2-Chloroethoxy)ethanol's Chemical Profile

2-(2-Chloroethoxy)ethanol is characterized by its physical appearance as a colorless to light yellow clear liquid. Its chemical formula, C4H9ClO2, and molecular weight of 124.57 g/mol are fundamental to its reactivity and utility in synthesis. With a boiling point of approximately 79-81°C at 5 mm Hg and a density of 1.18 g/mL, these properties are critical for chemists and manufacturers to effectively manage its use in various reaction processes. The compound's assay typically meets high purity standards, often exceeding 99.0%, which is a non-negotiable requirement in the pharmaceutical industry to minimize the presence of undesirable impurities like 2-Chloroethanol or 1,4-dioxane.

Key Applications in Pharmaceutical Synthesis

The most significant application of 2-(2-Chloroethoxy)ethanol lies in its function as a key intermediate for the synthesis of Active Pharmaceutical Ingredients (APIs). It is particularly renowned for its role in the production of Quetiapine and its fumarate salt. Quetiapine is a widely prescribed atypical antipsychotic medication used to treat conditions such as schizophrenia, bipolar disorder, and major depressive disorder. The precise chemical structure of 2-(2-Chloroethoxy)ethanol allows for its efficient incorporation into the complex molecular pathways required to build these life-changing drugs. Beyond Quetiapine, it is also an intermediate for other pharmaceutical compounds like Hydroxyzine HCl and Cetirizine HCl, further underscoring its importance in developing treatments for various health conditions.

Quality and Sourcing Considerations

For pharmaceutical companies, the procurement of 2-(2-Chloroethoxy)ethanol is a critical decision. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. emphasize the importance of consistent quality and reliable supply chains. The presence of stringent specifications for impurities, such as limits on 2-Chloroethanol, 1,4-dioxane, and 2,2-Dichlorodiethyl Ether, ensures that the intermediate contributes positively to the final API's safety and efficacy. The ability to purchase 2-(2-Chloroethoxy)ethanol with guaranteed high purity is essential for maintaining reproducible manufacturing processes and meeting regulatory standards. Companies seeking to buy 2-(2-Chloroethoxy)ethanol online or from reputable suppliers are advised to verify the detailed specifications and the manufacturer's commitment to quality assurance.

Conclusion

2-(2-Chloroethoxy)ethanol is more than just a chemical compound; it is an indispensable component in the pharmaceutical value chain. Its reliable chemical properties and critical role in synthesizing widely used medications solidify its position as a vital intermediate. As the demand for effective treatments grows, the consistent production and availability of high-quality 2-(2-Chloroethoxy)ethanol will remain a cornerstone of pharmaceutical innovation and accessibility.