The Crucial Role of 2,3-Dimethyl-6-nitro-2H-indazole in Pazopanib Synthesis
Pazopanib, a widely recognized oral angiogenesis inhibitor, has been instrumental in treating certain types of cancer, particularly renal cell carcinoma and soft tissue sarcoma. The efficacy and safety of this vital medication are highly dependent on the purity and precise synthesis of its constituent components. Among these, 2,3-Dimethyl-6-nitro-2H-indazole stands out as a critical intermediate, playing a pivotal role in the multi-step chemical synthesis of Pazopanib. Understanding the nuances of this compound is paramount for pharmaceutical manufacturers aiming to produce high-quality Pazopanib.
The chemical identity of 2,3-Dimethyl-6-nitro-2H-indazole is well-defined by its CAS number 444731-73-1. This organic compound, with the molecular formula C9H9N3O2, presents as a yellow powder. Its physical and chemical properties, including a melting point typically between 183-186°C and a density of approximately 1.37 g/cm³, are thoroughly documented. These characteristics are vital for handling, processing, and ensuring the compound's stability throughout the manufacturing process. The reliable supply of this intermediate is a cornerstone for any pharmaceutical company engaged in Pazopanib production.
The synthesis of 2,3-Dimethyl-6-nitro-2H-indazole often involves intricate organic chemistry pathways, with common methods starting from precursors like 3-methyl-6-nitro-1H-indazole. Manufacturers often employ N-alkylation reactions using methylating agents in specific solvent systems, followed by purification to achieve the desired high purity, often exceeding 98.0%. This stringent purity requirement is non-negotiable, as any impurities in this intermediate could propagate through the synthesis, potentially affecting the final Pazopanib product's efficacy and safety profile. This underscores the importance of sourcing this compound from reputable suppliers who adhere to strict quality control measures.
Beyond its role as a direct precursor, 2,3-Dimethyl-6-nitro-2H-indazole also functions as a critical reference standard for impurity profiling in Pazopanib manufacturing. Pharmaceutical quality control laboratories utilize it to identify and quantify trace amounts of this compound or related impurities that may arise during the synthesis or storage of the final drug product. This meticulous impurity analysis is a regulatory requirement and a fundamental aspect of ensuring patient safety. Therefore, the availability of certified reference standards of 2,3-Dimethyl-6-nitro-2H-indazole is essential for analytical method development and validation.
For companies seeking to purchase 2,3-Dimethyl-6-nitro-2H-indazole, understanding the supply chain and the expertise of the manufacturer is crucial. As a leading supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality chemical intermediates. Our commitment to excellence ensures that we contribute significantly to the pharmaceutical industry's ability to deliver safe and effective cancer treatments. By focusing on reliable synthesis, rigorous quality control, and transparent documentation, we support researchers and manufacturers in their pursuit of therapeutic advancements. The consistent availability and documented quality of 2,3-Dimethyl-6-nitro-2H-indazole empower the industry to meet global health challenges.
The chemical identity of 2,3-Dimethyl-6-nitro-2H-indazole is well-defined by its CAS number 444731-73-1. This organic compound, with the molecular formula C9H9N3O2, presents as a yellow powder. Its physical and chemical properties, including a melting point typically between 183-186°C and a density of approximately 1.37 g/cm³, are thoroughly documented. These characteristics are vital for handling, processing, and ensuring the compound's stability throughout the manufacturing process. The reliable supply of this intermediate is a cornerstone for any pharmaceutical company engaged in Pazopanib production.
The synthesis of 2,3-Dimethyl-6-nitro-2H-indazole often involves intricate organic chemistry pathways, with common methods starting from precursors like 3-methyl-6-nitro-1H-indazole. Manufacturers often employ N-alkylation reactions using methylating agents in specific solvent systems, followed by purification to achieve the desired high purity, often exceeding 98.0%. This stringent purity requirement is non-negotiable, as any impurities in this intermediate could propagate through the synthesis, potentially affecting the final Pazopanib product's efficacy and safety profile. This underscores the importance of sourcing this compound from reputable suppliers who adhere to strict quality control measures.
Beyond its role as a direct precursor, 2,3-Dimethyl-6-nitro-2H-indazole also functions as a critical reference standard for impurity profiling in Pazopanib manufacturing. Pharmaceutical quality control laboratories utilize it to identify and quantify trace amounts of this compound or related impurities that may arise during the synthesis or storage of the final drug product. This meticulous impurity analysis is a regulatory requirement and a fundamental aspect of ensuring patient safety. Therefore, the availability of certified reference standards of 2,3-Dimethyl-6-nitro-2H-indazole is essential for analytical method development and validation.
For companies seeking to purchase 2,3-Dimethyl-6-nitro-2H-indazole, understanding the supply chain and the expertise of the manufacturer is crucial. As a leading supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality chemical intermediates. Our commitment to excellence ensures that we contribute significantly to the pharmaceutical industry's ability to deliver safe and effective cancer treatments. By focusing on reliable synthesis, rigorous quality control, and transparent documentation, we support researchers and manufacturers in their pursuit of therapeutic advancements. The consistent availability and documented quality of 2,3-Dimethyl-6-nitro-2H-indazole empower the industry to meet global health challenges.
Perspectives & Insights
Quantum Pioneer 24
“Its physical and chemical properties, including a melting point typically between 183-186°C and a density of approximately 1.”
Bio Explorer X
“These characteristics are vital for handling, processing, and ensuring the compound's stability throughout the manufacturing process.”
Nano Catalyst AI
“The reliable supply of this intermediate is a cornerstone for any pharmaceutical company engaged in Pazopanib production.”