In the intricate world of pharmaceutical manufacturing, the quality and availability of key intermediates are paramount. One such compound, 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile (CAS: 82671-02-1), stands out for its critical role in the synthesis of essential medications, particularly broad-spectrum antibiotics. Understanding its significance, properties, and reliable sourcing is vital for any entity involved in drug development and production.

What is 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile?

Also known by synonyms such as 2,6-dichloro-3-cyano-5-fluoropyridine, this halogenated pyridine derivative is a chemical building block characterized by its unique structural features. Its molecular formula, C6HCl2FN2, and molecular weight of 190.99 g/mol, provide the foundation for its reactivity and utility in complex organic synthesis. Typically appearing as an off-white to light tan crystalline powder, it exhibits a purity of at least 98%, a specification crucial for pharmaceutical applications where impurities can significantly impact the final drug product's safety and efficacy. Its physical properties, including a melting point of 89-91°C, further underscore its stability and handling suitability in industrial settings.

The Link to Gemifloxacin and Beyond

The most prominent application of 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile is its indispensable role as an intermediate in the synthesis of Gemifloxacin mesylate. Gemifloxacin is a potent fluoroquinolone antibiotic used to treat serious bacterial infections, including community-acquired pneumonia and acute bacterial exacerbations of chronic bronchitis. The reliable supply of high-purity 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile directly impacts the availability of this life-saving medication. Beyond Gemifloxacin, this versatile compound serves as a molecular scaffold for other significant fluoroquinolone derivatives, such as Enoxacin, Trovafloxacin, and Tosufloxacin. This broad utility makes it a sought-after material for researchers and manufacturers aiming to develop new antibiotics or refine existing ones, potentially with improved efficacy or reduced side effects. For companies looking to buy this essential intermediate, understanding its applications is key to planning their procurement strategies.

Sourcing from China: A Strategic Advantage

China has established itself as a global powerhouse in the production of fine chemicals and pharmaceutical intermediates, offering a robust and cost-effective supply chain. For entities seeking 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile, partnering with a reputable Chinese manufacturer or supplier presents a significant strategic advantage. These manufacturers often leverage advanced synthesis technologies and adhere to stringent quality control measures, ensuring consistent product quality and reliable delivery. When you purchase this crucial building block from China, you benefit from competitive pricing without compromising on the high purity (≥98%) demanded by the pharmaceutical industry. This makes sourcing from China a practical and economical choice for maintaining your production pipelines.

Conclusion

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile is far more than just a chemical compound; it is a linchpin in the production of vital antibiotics that combat widespread infections. Its purity, stability, and versatility make it indispensable for pharmaceutical synthesis. For those in the industry, securing a consistent and high-quality supply of this intermediate, particularly from established Chinese manufacturers, is a critical step towards ensuring the availability of essential medicines. When considering your procurement needs, remember to inquire about bulk purchase options and obtain quotes from trusted suppliers to meet your manufacturing demands effectively.