In the competitive landscape of pharmaceutical manufacturing, the consistent supply of high-quality intermediates is paramount. One such critical component is 2-(Chloromethyl)-1,3-dioxolane (CAS 2568-30-1). This versatile chemical serves as an indispensable building block, particularly in the synthesis of Doxofylline, a widely prescribed bronchodilator used to treat respiratory ailments like asthma and COPD. Understanding the importance of this intermediate is key for procurement managers and R&D scientists aiming to optimize their production processes.

What is 2-(Chloromethyl)-1,3-dioxolane?

Chemically known as chloroacetaldehyde ethylene acetal, 2-(Chloromethyl)-1,3-dioxolane possesses a unique structure featuring a stable dioxolane ring coupled with a reactive chloromethyl group. This dual characteristic makes it an exceptionally useful intermediate in organic synthesis. Its physical properties include being a colorless liquid with a boiling point around 157-158°C and a density of 1.234 g/mL at 25°C. The presence of the chloromethyl group makes it an excellent electrophile, readily participating in nucleophilic substitution reactions, which is precisely its utility in pharmaceutical synthesis.

The Synthesis of Doxofylline: A Key Application

The primary driver for the demand of 2-(Chloromethyl)-1,3-dioxolane is its role in the industrial synthesis of Doxofylline. In this process, the theophylline molecule acts as a nucleophile, attacking the electrophilic carbon of the chloromethyl group. This alkylation reaction, facilitated by a base and often a solvent like acetone or DMF, efficiently attaches the dioxolane-containing side chain to the theophylline core, forming the Doxofylline molecule. The reaction is well-established, with manufacturers focusing on optimizing yields and purity through careful control of reaction conditions, catalyst selection, and efficient purification methods. This makes sourcing high-purity 2-(Chloromethyl)-1,3-dioxolane from a reliable manufacturer crucial for ensuring the efficacy and safety of the final drug product.

Sourcing and Supply Chain Considerations

For procurement managers, securing a consistent and cost-effective supply of 2-(Chloromethyl)-1,3-dioxolane is vital. As a leading supplier in China, we offer this critical intermediate, ensuring adherence to strict quality standards. We understand the importance of competitive pricing for bulk purchases and can provide detailed technical specifications and Certificates of Analysis (CoA) upon inquiry. Our robust manufacturing capabilities guarantee dependable availability, mitigating supply chain risks for your production needs. When you buy 2-(chloromethyl)-1,3-dioxolane, consider partnering with a supplier committed to quality and reliability.

Beyond Doxofylline: Other Applications

While Doxofylline synthesis remains its primary application, the inherent reactivity of 2-(Chloromethyl)-1,3-dioxolane extends its utility to other areas. It serves as a valuable building block in general organic synthesis for creating complex molecules, including certain agrochemicals like herbicide safeners. Furthermore, its derivatives are explored in polymer chemistry for the development of specialty materials with unique functional properties. Researchers are constantly investigating new synthetic routes and applications for this compound, emphasizing its broad chemical significance.

Conclusion

2-(Chloromethyl)-1,3-dioxolane (CAS 2568-30-1) is more than just a chemical intermediate; it is a critical enabler for the production of essential medicines like Doxofylline. For companies seeking a reliable supplier or a competitive price to buy this compound, understanding its applications and sourcing from reputable manufacturers is key. We invite you to connect with us to discuss your requirements and secure a consistent supply of this vital pharmaceutical intermediate.