In the complex world of pharmaceutical manufacturing, the quality and availability of key intermediates are paramount. One such critical compound is 2,4-Diamino-6-hydroxypyrimidine, identified by its CAS number 56-06-4. This versatile molecule serves as a foundational building block in the synthesis of numerous life-saving medications. For procurement managers and R&D scientists, understanding its significance and securing a reliable supply chain is essential.

Understanding 2,4-Diamino-6-hydroxypyrimidine's Functionality

At its core, 2,4-Diamino-6-hydroxypyrimidine is recognized for its role as a specific inhibitor of GTP cyclohydrolase I. This enzyme is a rate-limiting step in the de novo synthesis of pteridines, particularly tetrahydrobiopterin (BH4). BH4 is a crucial cofactor involved in various metabolic processes, including the synthesis of nitric oxide (NO). By modulating these pathways, compounds derived from 2,4-Diamino-6-hydroxypyrimidine can have significant therapeutic implications.

Applications in Drug Development

The primary value of 2,4-Diamino-6-hydroxypyrimidine lies in its utility as a pharmaceutical intermediate. Its chemical structure makes it an ideal precursor for a range of pharmaceutical agents:

  • Anti-anemia drugs: It is a well-established intermediate in the synthesis of Folic Acid, a vital nutrient for red blood cell formation and a cornerstone in treating various forms of anemia.
  • Antihypertensive medications: Derivatives of this compound have shown efficacy in developing drugs to manage high blood pressure, contributing to cardiovascular health.
  • Potential anti-cancer agents: Ongoing research explores its derivatives for their cytotoxic effects against cancer cells, highlighting its broad therapeutic potential.

For any organization looking to buy 2,4-Diamino-6-hydroxypyrimidine, ensuring high purity is non-negotiable. Impurities can drastically affect reaction yields and the efficacy of the final drug product. This is where sourcing from reputable manufacturers in China becomes critical. Chinese chemical manufacturers have become global leaders in producing high-quality pharmaceutical intermediates at competitive prices.

Sourcing Strategies for Procurement Professionals

Procurement managers seeking to secure a consistent supply of 2,4-Diamino-6-hydroxypyrimidine should focus on suppliers with a proven track record of quality control and reliable logistics. When evaluating potential suppliers, consider:

  • Purity levels: Look for materials with guaranteed purity of 97% min, or higher, to meet strict pharmaceutical standards.
  • Manufacturing capabilities: Verify the supplier's production capacity and their adherence to international quality standards.
  • Pricing and MOQ: Obtaining a competitive price for bulk orders is crucial for cost management. Understand the Minimum Order Quantity (MOQ) requirements.
  • Regulatory compliance: Ensure the supplier can provide necessary documentation, such as Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS).

The market for this essential intermediate is robust, with numerous companies offering it. However, selecting the right partner is key. By collaborating with experienced manufacturers in China, businesses can ensure they receive high-quality 2,4-Diamino-6-hydroxypyrimidine, facilitating the timely and cost-effective production of critical pharmaceuticals. Whether you are looking to purchase this compound for ongoing production or for new research initiatives, a strategic sourcing approach will yield the best results.