In the complex world of pharmaceutical manufacturing, the quality and consistency of intermediate compounds are paramount. One such critical intermediate is 4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride (CAS: 166975-76-4). This compound serves as a foundational building block, particularly in the synthesis of Raloxifene hydrochloride, a selective estrogen receptor modulator (SERM) widely prescribed for the treatment and prevention of osteoporosis in postmenopausal women. Understanding its properties and the importance of a reliable supply chain is essential for any pharmaceutical company seeking to optimize its production processes and ensure product efficacy.

The Significance of Purity and Stability

4-(2-Piperidin-1-ylethoxy)benzoic acid hydrochloride is typically supplied as a white to light yellow powder with a molecular formula of C14H20ClNO3 and a molecular weight of approximately 285.77 g/mol. Its assay purity, often exceeding 97%, is a critical factor for pharmaceutical synthesis, where even minor impurities can significantly impact the final Active Pharmaceutical Ingredient (API) quality and safety. Manufacturers who prioritize high purity are essential for meeting stringent regulatory standards. Furthermore, the compound exhibits notable chemical stability, characterized by a high boiling point (413.2°C at 760 mmHg) and flash point (203.7°C), which are advantageous during industrial synthesis processes that may involve elevated temperatures.

Key Applications in Drug Synthesis

The primary and most well-documented application of 4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride is its role as a precursor in the multi-step synthesis of Raloxifene hydrochloride. Raloxifene's therapeutic benefits in bone health and potential role in reducing breast cancer risk underscore the demand for its reliable production. This intermediate's specific chemical structure, featuring a piperidine ring connected via an ethoxy bridge to a benzoic acid core, makes it perfectly suited for the precise chemical transformations required to build the Raloxifene molecule. Beyond Raloxifene, its structural features suggest potential utility as a building block in the development of other novel pharmaceutical agents, making it a valuable compound for medicinal chemistry research.

Sourcing from a Trusted Manufacturer in China

For pharmaceutical companies, identifying a reputable 4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride manufacturer and supplier is paramount. China has emerged as a significant hub for chemical synthesis, offering competitive pricing and a vast manufacturing capacity. When seeking to buy this intermediate, buyers should prioritize suppliers that demonstrate a strong commitment to quality control, possess robust manufacturing capabilities, and can ensure a stable supply chain. A reliable manufacturer will not only provide the necessary documentation (like Certificates of Analysis) but also offer technical support and flexible packaging options, such as 25 kg drums, to meet diverse production needs. Businesses looking for a consistent and high-quality source for their Raloxifene hydrochloride intermediate needs should engage with experienced chemical suppliers who understand the critical requirements of the pharmaceutical industry.

In conclusion, 4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride is more than just a chemical compound; it is a vital link in the chain of producing life-enhancing pharmaceuticals. By ensuring a steady supply of high-purity material from trusted manufacturers, the industry can continue to develop and deliver essential medicines effectively.