In the ever-evolving pharmaceutical landscape, the quality and availability of key intermediates are paramount. 4-Hydroxy-D-phenylglycine (CAS 22818-40-2) stands out as a critical chiral building block, particularly vital for the production of widely used antibiotics such as amoxicillin and cefadroxil. As a leading manufacturer and supplier in China, understanding the properties and applications of this compound is essential for procurement managers and research scientists seeking reliable raw materials.

4-Hydroxy-D-phenylglycine, often appearing as a white or almost white crystalline powder, exhibits specific solubility characteristics – slightly soluble in ethanol and water, but readily soluble in acidic or alkaline solutions to form salts. This chemical behavior is instrumental in its integration into complex synthesis pathways. Its stringent quality standards, often specifying an assay of ≥ 99.00%, underscore its importance in producing APIs with high therapeutic efficacy and safety profiles. For those looking to buy this essential intermediate, identifying a reputable supplier that guarantees consistent purity and timely delivery is key.

The primary application driving demand for 4-Hydroxy-D-phenylglycine is its role in the synthesis of semisynthetic penicillin and cephalosporin antibiotics. It forms the essential side chain that imparts specific antibacterial properties to these life-saving drugs. Beyond its direct role in antibiotic manufacturing, it also finds application as a pharmaceutical impurity standard, a critical component for ensuring the quality control and regulatory compliance of final drug products. This dual utility highlights its indispensable nature in the pharmaceutical supply chain.

When sourcing, it's beneficial to inquire about the price and bulk availability from established Chinese manufacturers. These suppliers are often equipped to handle large-scale orders and provide comprehensive documentation, including Technical Data Sheets (TDS) and Material Safety Data Sheets (MSDS), facilitating a smooth procurement process. Engaging with a trusted manufacturer ensures not only competitive pricing but also adherence to international quality benchmarks, making the acquisition of 4-Hydroxy-D-phenylglycine a strategic move for pharmaceutical companies globally.