In the intricate world of biomolecular research and pharmaceutical development, the quality and specificity of building blocks are paramount. Among these, chiral amino acid derivatives play a critical role, and N-Acetyl-D-alanine, commonly known as Ac-D-Ala-OH (CAS No. 19436-52-3), stands out as a particularly valuable compound.

Ac-D-Ala-OH is a derivative of D-alanine, featuring an acetyl group attached to the alpha-amino nitrogen. This modification not only influences its chemical properties but also its utility in complex synthetic pathways. As a D-amino acid derivative, it is crucial for creating peptides with specific stereochemistry, which can have profound effects on biological activity, stability, and receptor binding. This specificity is often leveraged in the design of therapeutic peptides, where D-amino acids can confer resistance to enzymatic degradation, thereby increasing the peptide's in vivo half-life.

Why Ac-D-Ala-OH is Essential for Peptide Synthesis

The primary application of Ac-D-Ala-OH lies in solid-phase peptide synthesis (SPPS) and solution-phase synthesis. As a protected D-amino acid, it can be readily incorporated into growing peptide chains using standard coupling reagents. Its presence can be critical for:

  • Mimicking Natural Peptide Structures: Many biological peptides incorporate D-amino acids. Using Ac-D-Ala-OH allows researchers to synthesize analogs of naturally occurring peptides or to introduce D-amino acids to enhance stability or modulate activity.
  • Developing Protease-Resistant Peptides: L-amino acids are the natural building blocks of proteins and are readily degraded by proteases in the body. Incorporating D-amino acids, such as D-alanine (often acetylated for specific coupling procedures), can significantly increase a peptide's resistance to enzymatic cleavage, leading to improved bioavailability and therapeutic efficacy.
  • Creating Novel Therapeutic Agents: The pharmaceutical industry relies on compounds like Ac-D-Ala-OH for the synthesis of innovative peptide-based drugs. These can target a wide range of diseases, from metabolic disorders to infectious diseases and cancer.

For purchasing managers and R&D scientists, sourcing a reliable supplier of high-purity Ac-D-Ala-OH is a strategic imperative. NINGBO INNO PHARMCHEM CO.,LTD. is a premier manufacturer and supplier of this essential reagent, offering competitive pricing and a consistent, high-quality product.

Sourcing High-Quality Ac-D-Ala-OH

When seeking to buy Ac-D-Ala-OH, it is essential to partner with a manufacturer that prioritizes purity and consistency. NINGBO INNO PHARMCHEM CO.,LTD. is a leading N-Acetyl-D-alanine supplier in China, dedicated to meeting the stringent requirements of the global pharmaceutical and biotechnology sectors. Our commitment to quality control ensures that every batch of Ac-D-Ala-OH meets high standards, making us a trusted source for CAS 19436-52-3 price inquiries and bulk orders.

We understand that reliable supply chains are crucial for research continuity and production schedules. That's why we focus on being a dependable Ac-D-Ala-OH manufacturer, providing not only excellent products but also responsive customer service. Whether you are looking for peptide synthesis reagents for laboratory use or bulk quantities of chiral amino acid derivatives for sale, our team is ready to assist. Explore our offerings and discover why NINGBO INNO PHARMCHEM CO.,LTD. is the preferred partner for critical biochemical building blocks.