In the dynamic field of peptide synthesis, the selection of high-quality building blocks is paramount to success. Among these essential components, Boc-His(Tos)-OH stands out as a critical reagent. This N-alpha-Boc protected histidine derivative, identified by its CAS number 35899-43-5, plays a pivotal role in both solid-phase peptide synthesis (SPPS) and solution-phase methods. As a leading manufacturer and supplier of this key intermediate, we understand the meticulous requirements of researchers and pharmaceutical companies worldwide.

The structure of Boc-His(Tos)-OH incorporates a tert-butoxycarbonyl (Boc) protecting group on the alpha-amino group, which is standard for Boc SPPS strategies. More significantly, it features a p-toluenesulfonyl (Tos) group on the imidazole ring of histidine. This Tosyl protection is crucial because the imidazole nitrogen is nucleophilic and can interfere with coupling reactions or undergo side reactions if left unprotected during peptide chain elongation. The Tosyl group offers excellent stability under the conditions typically employed in Boc SPPS, yet it can be efficiently removed under mild acidic conditions, often with hydrogen fluoride (HF) or trifluoroacetic acid (TFA), after the peptide chain is assembled. This selective deprotection strategy ensures the integrity of the final peptide product.

For scientists and procurement managers seeking to buy Boc-His(Tos)-OH, understanding its application is key. Its primary use is in the construction of complex peptides that may be destined for therapeutic applications, diagnostic tools, or advanced biochemical research. The growing peptide drug market underscores the increasing demand for reliable and high-purity peptide synthesis reagents. This is precisely where a trusted supplier becomes indispensable. We pride ourselves on being a go-to manufacturer, ensuring consistent quality and availability for bulk purchases. When considering the price of Boc-His(Tos)-OH, investing in a high-purity product from a reputable source like ours can prevent costly synthesis failures and expedite your project timelines.

The advantages of using Boc-His(Tos)-OH from a dedicated supplier are manifold. Firstly, our stringent quality control processes guarantee the purity and consistency required for reproducible results, minimizing lot-to-lot variability. Secondly, as a manufacturer based in China, we offer a competitive edge in pricing and supply chain reliability, crucial for managing research budgets and production schedules. Whether you are developing novel peptide-based pharmaceuticals or exploring fundamental biological processes, our Boc-His(Tos)-OH provides the foundational support your research deserves. For an accurate price quote or to discuss bulk order inquiries, please contact our knowledgeable sales team.