In the demanding field of hematology, accurate and reliable test results are paramount. Blood collection tubes are the initial critical step in obtaining viable samples for analysis. Within these tubes, anticoagulants play a pivotal role in preventing the natural clotting process of blood. Among the most widely used and effective anticoagulants for hematological testing is Dipotassium EDTA (CAS 25102-12-9). As a leading supplier of high-quality laboratory reagents, we understand the importance of this compound and its contribution to diagnostic precision.

What is Dipotassium EDTA?

Dipotassium EDTA, chemically known as ethylenediaminetetraacetic acid dipotassium salt dihydrate, is a white, crystalline powder. Its efficacy as an anticoagulant stems from its powerful chelating properties. EDTA readily binds to calcium ions (Ca2+), which are essential cofactors in the blood coagulation cascade. By sequestering these calcium ions, Dipotassium EDTA effectively interrupts the clotting process, rendering the blood sample incoagulable. This makes it an ideal additive for blood collection tubes intended for routine hematology tests.

Why is Dipotassium EDTA Preferred for Hematology?

Several key advantages make Dipotassium EDTA the anticoagulant of choice for hematology:

  • Preservation of Cellular Morphology: Unlike some other anticoagulants, Dipotassium EDTA exhibits minimal distortion of blood cell morphology. It preserves the shape and size of red blood cells, white blood cells, and platelets, which are critical parameters evaluated in a complete blood count (CBC) and differential analysis. This preservation ensures that diagnostic evaluations are based on accurate cellular representations.
  • White Blood Cell Integrity: It does not significantly affect the count or size of white blood cells, maintaining their integrity for differential counting, a crucial step in diagnosing infections and inflammatory conditions.
  • Platelet Inhibition: While it prevents clotting, Dipotassium EDTA also effectively inhibits platelet aggregation. This is important for accurate platelet counts and morphology assessment.
  • Stability for Analysis: Samples collected in EDTA tubes maintain their cellular integrity for a reasonable period, allowing for timely and accurate testing without immediate processing.

Key Considerations for Use and Sourcing

While Dipotassium EDTA is highly effective, proper handling and sourcing are essential. As a direct manufacturer, we ensure our Dipotassium EDTA (CAS 25102-12-9) meets stringent purity standards (≥99.0%). Proper mixing is crucial; the blood sample must be gently inverted 5-8 times after collection to ensure thorough contact with the EDTA coating, preventing micro-clot formation. It's important to note that EDTA anticoagulation is irreversible, and samples should ideally be tested within 24 hours for optimal results. For those looking to buy Dipotassium EDTA, understanding its properties and sourcing from a reliable manufacturer like us is key to consistent laboratory performance.

Investing in high-quality Dipotassium EDTA is an investment in the accuracy and reliability of your hematology department. When you require a trusted supplier for this vital reagent, consider our commitment to quality and consistent supply.