In the intricate world of pharmaceutical manufacturing, the quality of intermediate compounds directly dictates the efficacy and safety of the final drug product. Among these critical intermediates, Ethyl 4-(1-Methyl-5-nitrobenzimidazol-2-yl)butanoate stands out, particularly for its indispensable role in the synthesis of Bendamustine, a potent chemotherapeutic agent. Understanding the properties and reliable sourcing of this compound is paramount for manufacturers aiming to produce high-quality cancer treatments.

Ethyl 4-(1-Methyl-5-nitrobenzimidazol-2-yl)butanoate, identified by CAS Number 3543-72-4, is a fine chemical intermediate characterized by its white crystalline powder appearance and a high purity level of ≥99%. Its molecular formula, C14H17N3O4, and molecular weight of 291.30200, provide the foundational structure for complex molecular assembly. The compound's physical properties, such as a density of 1.3 g/cm³, a boiling point of 481ºC, and a flash point of 244.7ºC, are important considerations for handling and processing within manufacturing environments.

The primary application of this nitrobenzimidazole derivative lies in its function as a precursor for Bendamustine hydrochloride, a drug widely used in the treatment of chronic lymphocytic leukemia (CLL) and certain types of lymphomas. Bendamustine functions as an alkylating agent, disrupting DNA synthesis and leading to cell death, making it a cornerstone in many cancer treatment regimens. The precise chemical structure of Ethyl 4-(1-Methyl-5-nitrobenzimidazol-2-yl)butanoate ensures the correct formation of Bendamustine's active molecular structure.

For pharmaceutical companies, securing a consistent and high-quality supply of such intermediates is crucial. Sourcing from a reputable manufacturer in China, like NINGBO INNO PHARMCHEM CO.,LTD., offers significant advantages. These include competitive pricing, adherence to strict quality control measures, and streamlined logistics, ensuring that production timelines are met without compromising on product integrity. The ability to purchase high-purity chemical intermediates directly contributes to the overall efficiency and cost-effectiveness of drug manufacturing.

When considering the purchase of Ethyl 4-(1-Methyl-5-nitrobenzimidazol-2-yl)butanoate, it is essential to look for suppliers who provide comprehensive documentation, including Certificates of Analysis (CoA) that confirm the purity and specifications. Furthermore, understanding the recommended storage conditions – typically in a cool, dry, well-closed container, away from moisture and strong light/heat – is vital for maintaining the compound's stability and efficacy over time. This attention to detail in handling and storage ensures that the intermediate performs as expected in the subsequent synthesis steps.

In summary, Ethyl 4-(1-Methyl-5-nitrobenzimidazol-2-yl)butanoate is more than just a chemical compound; it is a critical enabler for advanced pharmaceutical production, particularly in the fight against cancer. Its reliable supply and consistent quality, backed by experienced manufacturers, are indispensable for advancing healthcare solutions globally.