The Crucial Role of (R)-Tetrahydrofuran-2-carboxylic Acid in Drug Synthesis
In the intricate world of pharmaceutical manufacturing, specific chiral building blocks are indispensable for creating effective and safe medications. Among these, (R)-Tetrahydrofuran-2-carboxylic Acid stands out as a particularly important intermediate. Its unique stereochemistry and functional groups make it a cornerstone for synthesizing a wide range of Active Pharmaceutical Ingredients (APIs). For procurement managers and R&D scientists seeking high-quality materials, understanding the applications and sourcing of this compound is paramount.
(R)-Tetrahydrofuran-2-carboxylic Acid, often referred to by its CAS number 87392-05-0, is a heterocyclic carboxylic acid. Its chemical structure lends itself to being a versatile precursor in complex organic synthesis pathways. The demand for enantiomerically pure compounds in pharmaceuticals has grown exponentially, as even minor stereoisomers can drastically alter a drug's efficacy and safety profile. This is where compounds like (R)-Tetrahydrofuran-2-carboxylic Acid shine, enabling the precise construction of desired molecular architectures.
One of the most significant applications of (R)-Tetrahydrofuran-2-carboxylic Acid is in the synthesis of β-lactam antibiotics. These antibiotics are a critical class of drugs used to combat bacterial infections. For instance, it serves as a key intermediate in the production of Faropenem sodium. The precise stereochemistry provided by this building block is crucial for the final antibiotic's ability to inhibit bacterial cell wall synthesis effectively. Researchers looking to buy this component for antibiotic development will find its consistent quality essential.
Furthermore, (R)-Tetrahydrofuran-2-carboxylic Acid plays a role in the creation of antiviral medications. It is notably used in the synthesis of Baloxavir Marboxil, an important drug for treating influenza. The growing need for effective antiviral therapies underscores the strategic importance of securing a reliable supply of intermediates like this. Pharmaceutical companies requiring these compounds for their drug development pipelines actively seek manufacturers who can guarantee purity and scalability.
Beyond its roles in antibiotics and antivirals, this chiral intermediate is also employed in the synthesis of drugs targeting other therapeutic areas, including hypertension and certain types of cancer. The ability to reliably obtain (R)-Tetrahydrofuran-2-carboxylic Acid allows chemists to explore and develop novel treatments for a broad spectrum of diseases. The price and availability from reputable suppliers in China are key factors for companies managing their R&D budgets and production timelines.
For procurement professionals, identifying a trusted manufacturer and supplier is a critical step. Factors such as product specifications, purity levels (both chemical and optical), and manufacturing capacity are crucial considerations. Companies that can consistently deliver (R)-Tetrahydrofuran-2-carboxylic Acid with high optical purity (e.g., ≥ 95.0% e.e.) are invaluable partners. When searching to buy, it's advisable to look for suppliers who can also provide comprehensive technical data and support, ensuring seamless integration into your synthesis processes.
In summary, (R)-Tetrahydrofuran-2-carboxylic Acid is far more than just a chemical reagent; it is a fundamental building block enabling advancements in critical pharmaceutical sectors. Its applications span from combating infections to managing chronic conditions, making it a compound of significant commercial and medical importance. Securing a stable and high-quality supply is a strategic imperative for any pharmaceutical company engaged in the synthesis of these vital medicines.
Perspectives & Insights
Data Seeker X
“Researchers looking to buy this component for antibiotic development will find its consistent quality essential.”
Chem Reader AI
“Furthermore, (R)-Tetrahydrofuran-2-carboxylic Acid plays a role in the creation of antiviral medications.”
Agile Vision 2025
“It is notably used in the synthesis of Baloxavir Marboxil, an important drug for treating influenza.”