In the intricate world of pharmaceutical manufacturing, the selection of high-quality intermediates is paramount. One such essential compound is (S)-4-Chloro-3-hydroxybutyronitrile (CAS: 127913-44-4). This chiral building block plays a significant role in the synthesis of numerous active pharmaceutical ingredients (APIs), underscoring its importance for any pharmaceutical manufacturer aiming for precision and efficacy in their products.

(S)-4-Chloro-3-hydroxybutyronitrile is particularly noted for its utility as a precursor in the synthesis of atorvastatin. Atorvastatin is a widely prescribed statin medication used to lower cholesterol levels and reduce the risk of cardiovascular events. The specific chiral configuration of (S)-4-Chloro-3-hydroxybutyronitrile is critical for the correct stereochemistry of the final atorvastatin molecule, ensuring its pharmacological activity and safety profile. For pharmaceutical companies, sourcing reliable suppliers of this key intermediate is crucial for maintaining consistent production and quality control. The availability and price of such intermediates can directly impact manufacturing costs and timelines.

Beyond its role in atorvastatin synthesis, (S)-4-Chloro-3-hydroxybutyronitrile is also a vital intermediate in the creation of hydroxypyrrolidinones. These compounds are essential precursors for carbapenem antibiotics. Carbapenems are a class of beta-lactam antibiotics that are very broad-spectrum and particularly effective against many Gram-positive and Gram-negative bacteria, often reserved for more severe infections. The synthesis of these complex molecules requires highly specific chiral starting materials, making (S)-4-Chloro-3-hydroxybutyronitrile an indispensable component in their manufacturing process.

The demand for high-purity chiral intermediates like (S)-4-Chloro-3-hydroxybutyronitrile continues to grow as the pharmaceutical industry increasingly focuses on developing enantiomerically pure drugs. These pure enantiomers often exhibit improved therapeutic efficacy and reduced side effects compared to racemic mixtures. This trend drives the need for specialized chemical suppliers who can consistently deliver intermediates meeting stringent purity and chiral integrity standards. Pharmaceutical manufacturers actively seek partners who can provide detailed product specifications and certificates of analysis to ensure compliance with regulatory requirements.

For those in the pharmaceutical sector looking to secure a stable supply of this critical compound, understanding the market dynamics and key suppliers is essential. Purchasing (S)-4-Chloro-3-hydroxybutyronitrile involves more than just a transaction; it's about building a relationship with a reliable manufacturer who prioritizes quality, consistency, and timely delivery. Exploring options for purchasing (S)-4-Chloro-3-hydroxybutyronitrile often involves looking at different pack sizes, from R&D quantities to bulk orders, and comparing prices from reputable suppliers. The ability to obtain a free sample can also be invaluable for validation before committing to larger orders.

In summary, (S)-4-Chloro-3-hydroxybutyronitrile is far more than just a chemical compound; it is a foundational element in the production of life-saving medications. Its role in the synthesis of atorvastatin and carbapenem precursors highlights its indispensable nature in modern pharmaceutical manufacturing. For companies engaged in drug development and production, ensuring a consistent and high-quality supply of this chiral intermediate is a strategic imperative for success.