In the intricate world of organic synthesis, certain building blocks stand out for their versatility and critical role in constructing complex molecules. 2-Bromo-5-formylpyridine, also known by its CAS number 149806-06-4, is one such compound that has gained significant traction, particularly within the pharmaceutical and fine chemical industries. As a key intermediate, understanding its properties and applications is vital for researchers and procurement managers seeking to optimize their synthetic strategies.

Understanding 2-Bromo-5-formylpyridine

This pyridine derivative features both a bromine atom and a formyl (aldehyde) group strategically positioned on the pyridine ring. This bifunctional nature makes it an exceptionally useful starting material for a wide array of chemical transformations. Its structure allows for diverse coupling reactions, nucleophilic substitutions, and modifications of the aldehyde group, opening pathways to numerous advanced intermediates and target molecules. When you need to buy chemical intermediates, a compound like this offers significant synthetic advantage.

Key Applications in Synthesis

The utility of 2-Bromo-5-formylpyridine is well-documented in chemical literature and patents. It is frequently employed in:

  • Wittig Reactions: The aldehyde functionality readily participates in Wittig reactions to form new carbon-carbon double bonds, essential for creating unsaturated systems found in many pharmaceuticals and natural products.
  • Hydrodehalogenation: The bromine atom can be selectively removed through hydrodehalogenation, allowing for the introduction of hydrogen or further functionalization at that position. This process is key when targeting specific regiochemistry.
  • Cross-Coupling Reactions: The aryl bromide moiety is an excellent substrate for palladium-catalyzed cross-coupling reactions such as Suzuki, Heck, and Sonogashira couplings, enabling the formation of complex biaryl systems or alkynylated pyridines.
  • Formation of Heterocycles: It serves as a precursor for synthesizing more complex heterocyclic systems, which are prevalent in drug discovery.

For procurement managers, ensuring a stable supply of high-purity 2-Bromo-5-formylpyridine is paramount. As a leading manufacturer and supplier, we understand the importance of reliability and consistency in research and development. Our commitment is to provide researchers with the quality materials they need to push the boundaries of chemical innovation.

Why Partner with a Reliable Manufacturer?

Sourcing critical chemical intermediates like 2-Bromo-5-formylpyridine from a reputable manufacturer offers several advantages. Firstly, guaranteed high purity (often >98%) ensures that your reactions proceed as expected, minimizing by-products and saving valuable time and resources. Secondly, a reliable supplier provides consistent quality across batches, which is crucial for reproducible results in research and scaled-up production. Finally, choosing a manufacturer with a strong presence, especially a trusted chemical supplier in China, often translates to competitive pricing and efficient logistics.

If your research or manufacturing process requires 2-Bromo-5-formylpyridine, engaging with experienced suppliers can significantly streamline your procurement process. We invite you to contact us to learn more about our product specifications, pricing, and how we can support your chemical sourcing needs. Discover the difference quality and reliability can make to your projects.