In the intricate world of pharmaceutical development, the precise three-dimensional arrangement of atoms within a molecule—its chirality—is paramount. Chirality dictates how a drug interacts with biological targets, influencing its efficacy, safety, and metabolism. As such, access to high-purity chiral building blocks is a cornerstone for innovative drug discovery. One such critical intermediate is (1R,2S)-1-tert-Butoxycarbonylamino-2-vinylcyclopropanecarboxylic acid (CAS: 159622-10-3).

This compound, characterized by its specific (1R,2S) stereochemistry, features a tert-butoxycarbonyl (Boc) protecting group on the amine and a reactive vinyl moiety attached to a cyclopropane ring. These structural elements make it exceptionally valuable for medicinal chemists and process development teams. The cyclopropane ring offers rigidity and unique conformational constraints, often leading to improved pharmacokinetic properties and target binding affinity in drug candidates. The vinyl group serves as an excellent handle for further functionalization through various organic reactions, such as cross-coupling or cycloadditions, allowing for the rapid construction of complex molecular scaffolds.

The Boc-protected amine is a standard functional group in organic synthesis, enabling selective deprotection and subsequent modification without affecting other sensitive parts of the molecule. This controlled reactivity is vital for multi-step syntheses, ensuring high yields and purity of the desired end product. Researchers frequently seek out suppliers who can provide this intermediate with guaranteed enantiomeric purity, as even small amounts of the incorrect stereoisomer can lead to reduced efficacy or unwanted side effects.

Notably, (1R,2S)-1-tert-Butoxycarbonylamino-2-vinylcyclopropanecarboxylic acid is a key intermediate in the synthesis of Asunaprevir, a direct-acting antiviral agent. Its role highlights the importance of reliable sourcing for critical pharmaceutical intermediates. For companies looking to buy this essential compound, partnering with a reputable manufacturer and supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures consistent quality, competitive pricing, and stable supply chains. We understand the stringent requirements of pharmaceutical research and development and are dedicated to providing the high-purity chiral building blocks needed to accelerate your projects. If you are seeking a reliable source for this compound or require custom synthesis solutions, we encourage you to contact us for a quote and discuss how we can support your next groundbreaking discovery.