In the intricate world of pharmaceutical research and development, precision is paramount. For scientists delving into the complexities of cellular signaling and disease mechanisms, access to highly specific and potent chemical tools is essential. One such invaluable compound is 1-NM-PP1, a cell-permeable analog of PP1 that has emerged as a powerful tool for researchers focused on kinases. As a leading manufacturer and supplier of high-quality pharmaceutical intermediates, we are dedicated to providing the scientific community with the essential compounds needed to drive innovation.

1-NM-PP1, identified by its CAS number 221244-14-0, is renowned for its ability to selectively inhibit kinases that have been engineered to be 'analog-sensitive' (as), differentiating them from their wild-type counterparts. This selective inhibition is achieved through an ATP-competitive mechanism, allowing researchers to dissect the specific roles of particular kinase variants in biological processes. The compound's potency is underscored by its low IC50 values against various mutant kinases, often in the nanomolar range, which is significantly lower than its activity against wild-type kinases. This characteristic makes it an ideal choice for experiments requiring precise control over kinase activity.

The applications of 1-NM-PP1 span across numerous research disciplines. In drug discovery, it serves as a critical pharmaceutical intermediate, enabling the study of novel therapeutic targets and the screening of potential drug candidates. Its specific action against mutated kinases is particularly relevant in oncology, where aberrant kinase activity is a hallmark of many cancers. By utilizing 1-NM-PP1, researchers can gain deeper insights into disease pathways and explore the potential of targeted therapies. For those looking to buy 1-NM-PP1, partnering with a reliable manufacturer in China ensures not only product quality but also a stable supply chain, crucial for ongoing research projects.

Beyond drug development, 1-NM-PP1 is extensively used in fundamental cell signaling research. Scientists employ it to understand the intricate cascades that regulate cell growth, differentiation, and survival. The ability to specifically modulate the activity of mutated kinases allows for the detailed mapping of signaling networks and the identification of key regulatory points. For researchers needing to purchase 1-NM-PP1, our commitment to high purity and rigorous quality control ensures that you receive a product that meets the demanding standards of scientific investigation. We are proud to be a trusted supplier, offering competitive pricing and efficient delivery for this essential biochemical.

In summary, 1-NM-PP1 represents a significant advancement in the toolkit available to researchers in the life sciences. Its unique selectivity and potency make it indispensable for targeted kinase inhibition studies and the broader pursuit of novel therapeutics. We invite you to explore our offerings and learn how our commitment as a premier manufacturer and supplier of 1-NM-PP1 can support your groundbreaking research. Contact us today to request a quote and sample, and discover the difference that quality and precision can make in your work.