In the fast-paced world of pharmaceutical research and development, precision is paramount. Every experiment, every analysis, and every step towards a new therapeutic hinges on the accuracy of the data generated. This is where specialized reagents like isotopically labeled compounds become indispensable. Among these, Folic Acid labeled with Carbon-13 (13C5) and Nitrogen-15 (15N), identified by CAS number 2687960-47-8, stands out as a powerful tool for gaining deeper insights into biological processes and accelerating drug discovery.

Folic acid, also known as Vitamin B9, plays a critical role in numerous cellular functions, including DNA synthesis, repair, and methylation. Its importance in human health is well-established, particularly during periods of rapid growth and cell division. However, understanding its precise journey within the body, how it interacts with other molecules, and how potential therapeutic compounds affect its metabolism requires a level of detail that conventional methods often cannot provide.

This is where the power of isotopic labeling comes into play. By replacing specific atoms within the folic acid molecule with their stable isotopes (13C and 15N), researchers create a 'tracer' molecule. This labeled folic acid behaves chemically and biologically almost identically to its unlabeled counterpart, allowing it to be administered to biological systems (in vitro or in vivo). The key difference lies in its unique isotopic signature, which can be detected and quantified using advanced analytical techniques like Mass Spectrometry (MS).

For pharmaceutical manufacturers and R&D teams, this offers several critical advantages:

1. Enhanced Pharmacokinetic (PK) and ADME Studies: Understanding how a drug is absorbed, distributed, metabolized, and excreted is fundamental. When developing drugs that interact with folate pathways or are themselves folate analogs, using labeled folic acid allows researchers to meticulously track its fate. This provides invaluable data for dose optimization, predicting efficacy, and identifying potential drug-drug interactions. A reliable supplier of these high-purity labeled compounds is crucial for consistent PK data.

2. Precise Metabolic Pathway Elucidation: Folic acid is a central player in one-carbon metabolism. Labeled folic acid enables scientists to trace the flow of carbon and nitrogen atoms through complex biochemical pathways. This is vital for understanding disease mechanisms, identifying new drug targets, and developing therapies that modulate these pathways. For example, researchers can precisely determine the metabolic fate of a drug candidate that is designed to mimic or interfere with folic acid's function.

3. Robust Analytical Method Development and Validation: Developing accurate and reliable analytical methods for quantifying endogenous or exogenous compounds in biological samples is a cornerstone of pharmaceutical research. Labeled folic acid serves as an ideal internal standard for LC-MS/MS assays. Its near-identical chemical properties to the analyte, coupled with its distinct isotopic mass, allow for highly sensitive and specific quantification, ensuring the validity of research findings.

4. Advancing Nutritional Science and Supplement Research: Beyond drug development, labeled folic acid is instrumental in nutritional research. It helps investigate nutrient absorption, bioavailability, and the impact of dietary interventions or supplements on folate status. For companies producing dietary supplements, having access to high-quality labeled folic acid from a reputable manufacturer is key to substantiating product claims.

As a leading manufacturer and supplier of high-purity isotope-labeled compounds, we are dedicated to empowering scientific innovation. Our Folic Acid-13C5, 15N (CAS: 2687960-47-8) is produced with stringent quality controls, ensuring the high isotopic enrichment and chemical purity necessary for your most demanding research applications. We understand the critical nature of these reagents and are committed to providing consistent supply and competitive pricing. When you need to buy research-grade materials that deliver uncompromising accuracy, partner with a trusted manufacturer. Inquire today about our labeled folic acid and explore how precision can accelerate your R&D journey.