Asthma remains a significant global health challenge, characterized by chronic airway inflammation and hyperresponsiveness. For pharmaceutical professionals seeking effective active pharmaceutical ingredients (APIs), understanding the mechanisms and benefits of compounds like Seratrodast is crucial. As a premier supplier and manufacturer, we delve into why Seratrodast is a critical component in modern asthma therapeutics.

What is Seratrodast?

Seratrodast, identified by CAS number 112665-43-7, is a potent and highly selective antagonist of the thromboxane A2 receptor (TP receptor). This makes it a valuable pharmaceutical intermediate for drug formulations targeting respiratory diseases. Its primary application lies in its ability to counteract the detrimental effects of thromboxane A2 (TXA2), a naturally occurring substance in the body that can exacerbate asthma symptoms.

Mechanism of Action: Targeting TXA2 for Respiratory Relief

In individuals with asthma, TXA2 contributes to several key pathological processes: airway smooth muscle contraction, increased plasma extravasation (leading to airway wall edema), and airway hyper-responsiveness. Seratrodast effectively blocks these actions by antagonizing the TP receptor. By preventing TXA2 from binding to its receptor, Seratrodast helps to:

  • Relax contracted airway smooth muscles, improving airflow.
  • Reduce leakage from blood vessels in the airways, minimizing swelling and congestion.
  • Mitigate the overall hyper-responsiveness of the airways to various stimuli.

This targeted action provides a significant therapeutic advantage in managing the complex inflammatory processes of asthma.

Clinical Efficacy and Applications

Extensive clinical studies have validated the efficacy of Seratrodast. It has demonstrated significant improvements in lung function parameters such as FEV1 (Forced Expiratory Volume in 1 second), FVC (Forced Vital Capacity), and PEF (Peak Expiratory Flow). Furthermore, patients treated with Seratrodast have reported substantial reductions in common asthma symptoms like wheezing, shortness of breath, and chest tightness. Beyond asthma, Seratrodast has also shown promise in treating allergic rhinitis and chronic bronchitis. For those looking to buy Seratrodast for these indications, sourcing from a reliable manufacturer in China ensures quality and consistency.

Why Source from a Reputable Manufacturer?

As a trusted pharmaceutical ingredient manufacturer and supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. understands the critical importance of purity, consistency, and reliability. When you purchase Seratrodast from us, you are assured of a product that meets stringent quality standards, essential for pharmaceutical applications. We provide competitive pricing and a stable supply chain, supporting your production needs for respiratory therapeutics. Explore our offerings to secure a high-quality TP receptor antagonist for your product development.

For procurement inquiries or to request a sample of Seratrodast, please contact us today. Partner with NINGBO INNO PHARMCHEM CO.,LTD. for your pharmaceutical intermediate needs.