In the dynamic field of regenerative medicine and cell therapy, the efficient expansion of hematopoietic stem cells (HSCs) is a critical bottleneck. Researchers are constantly seeking reliable methods and high-quality reagents to support these complex processes. Among the key compounds employed, 16,16-Dimethyl Prostaglandin E2 has emerged as a significant player, offering unique advantages for maintaining stem cell viability and self-renewal properties during in vitro culture.

16,16-Dimethyl Prostaglandin E2 (CAS 39746-25-3) is a synthetic analog of prostaglandin E2, meticulously designed to overcome the metabolic limitations of its natural counterpart. Unlike endogenous PGE2, this derivative exhibits remarkable resistance to degradation by the enzyme 15-hydroxy PGDH. This enhanced stability translates to a prolonged half-life in vivo and, crucially, in the controlled environment of cell culture. This extended presence allows for sustained interaction with cellular targets, thereby preserving the delicate balance required for stem cell self-renewal.

The mechanism by which 16,16-Dimethyl Prostaglandin E2 influences stem cell populations is multifaceted. It acts as a potent agonist for various prostaglandin E (EP) receptor subtypes. When applied to cell cultures, it has been observed to increase hematopoietic stem and progenitor cell (HSPC) numbers, particularly in contexts like zebrafish aorta-gonad-mesonephros (AGM) regions and mouse bone marrow. Furthermore, it plays a role in mediating the effects of WNT signaling pathways, which are themselves central to stem cell self-renewal and differentiation. By modulating these pathways, 16,16-Dimethyl Prostaglandin E2 helps to prevent premature differentiation, ensuring a larger pool of undifferentiated stem cells available for further research or therapeutic application.

For procurement managers and research scientists in the pharmaceutical industry, sourcing high-quality 16,16-Dimethyl Prostaglandin E2 is paramount. Reliability, purity, and consistent supply are key considerations. As a dedicated manufacturer and supplier of advanced biochemicals, we understand these needs. We offer 16,16-Dimethyl Prostaglandin E2 with a guaranteed purity of 99%, ensuring that your experiments yield reproducible and accurate results. Our commitment to quality extends to providing a stable supply chain, allowing you to purchase this vital compound with confidence. Whether you are initiating a new research project or scaling up existing protocols, understanding the 'price' and availability from a trusted 'manufacturer in China' is essential.

By utilizing 16,16-Dimethyl Prostaglandin E2, researchers can significantly enhance their ability to expand and maintain critical stem cell populations. This is particularly relevant in areas such as bone marrow transplantation, gene therapy, and the development of personalized medicine. If you are looking to 'buy' this essential research chemical, consider partnering with a supplier that prioritizes purity, efficacy, and customer support. We are equipped to provide detailed specifications and timely delivery to meet your research demands.