In the intricate landscape of pharmaceutical development, the selection of appropriate chemical intermediates is a cornerstone of successful drug synthesis. 2,5-Dibromothioanisole, identified by its CAS number 134646-03-0, has emerged as a compound of significant importance in this domain. Its unique chemical structure and reactivity make it an invaluable asset for researchers aiming to synthesize novel therapeutic agents.

2,5-Dibromothioanisole: A Strategic Intermediate

2,5-Dibromothioanisole is an organosulfur compound characterized by its molecular formula C7H6Br2S. The presence of two bromine atoms on the aromatic ring, specifically at the 2 and 5 positions, imparts distinct advantages for synthetic chemists. These bromine atoms serve as highly reactive sites that can be readily manipulated through a variety of chemical transformations. Most notably, they are excellent substrates for palladium-catalyzed cross-coupling reactions, a fundamental tool in modern organic synthesis for forming new carbon-carbon and carbon-heteroatom bonds.

Key Synthetic Advantages for Pharma

  • Versatile Functionalization: The two bromine atoms allow for sequential or differential functionalization, enabling the introduction of diverse chemical groups and the construction of complex molecular scaffolds necessary for drug design.
  • Cross-Coupling Reactions: Its suitability for reactions like Suzuki, Stille, and Heck couplings makes it a robust intermediate for efficiently building intricate molecular frameworks.
  • Scaffold for Bioactive Molecules: The thioanisole core itself, when further functionalized, can contribute to the biological activity of the final compound.

Applications in Drug Discovery and Development

The primary driver for the demand of 2,5-Dibromothioanisole (CAS 134646-03-0) in the pharmaceutical sector is its role as an intermediate in the synthesis of active pharmaceutical ingredients (APIs). Researchers utilize this compound to:

  • Synthesize novel drug candidates for various therapeutic targets.
  • Create analogues of existing drugs to improve efficacy, reduce side effects, or overcome resistance.
  • Develop radiolabeled compounds for diagnostic imaging or pharmacokinetic studies.

When considering the purchase of this crucial intermediate, ensuring high purity is paramount, as impurities can significantly impact downstream reactions and the quality of the final API. A purity of ≥95% is typically desired.

Sourcing from Expert Manufacturers

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier of 2,5-Dibromothioanisole in China. We are dedicated to providing the pharmaceutical industry with high-quality intermediates that meet stringent purity requirements. Our manufacturing capabilities, coupled with our commitment to rigorous quality control, ensure that you receive a reliable product for your critical synthesis needs. We understand the importance of a consistent and dependable supply chain for pharmaceutical production. To buy 2,5-Dibromothioanisole with confidence, contact us for a quote and to discuss your project requirements. We are your trusted partner for advanced pharmaceutical intermediates.