In the ever-evolving landscape of pharmaceutical research and development, the availability of high-quality, versatile chemical intermediates is paramount. Among these critical compounds, 2-Amino-5-bromopyridin-3-ol (CAS: 39903-01-0) has emerged as a key building block, particularly in the synthesis of sophisticated drug molecules. As a dedicated manufacturer and supplier from China, we understand the immense value this compound brings to medicinal chemists and formulation scientists.

This article delves into the significance of 2-Amino-5-bromopyridin-3-ol, exploring its structural attributes, synthetic utility, and its pivotal role in the development of cutting-edge therapeutics, especially kinase inhibitors. Understanding its applications can empower researchers to optimize their drug discovery pipelines and secure reliable sourcing for their critical projects.

Understanding 2-Amino-5-bromopyridin-3-ol: A Chemist's Perspective

2-Amino-5-bromopyridin-3-ol is a substituted pyridine derivative characterized by an amino group at the 2-position, a bromine atom at the 5-position, and a hydroxyl group at the 3-position. This trifunctional nature imbues the molecule with significant chemical reactivity, making it an attractive precursor for a wide range of complex organic syntheses. The bromine atom, in particular, serves as an excellent handle for palladium-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, and Buchwald-Hartwig aminations, allowing for the introduction of diverse aryl, alkynyl, and amino substituents. The amino and hydroxyl groups also provide sites for further functionalization or participation in hydrogen bonding interactions, crucial for molecular recognition in biological systems.

The Rise of Kinase Inhibitors and the Role of Our Intermediate

One of the most impactful applications of 2-Amino-5-bromopyridin-3-ol lies in the synthesis of kinase inhibitors. Kinases are enzymes that play critical roles in cell signaling pathways, and their dysregulation is implicated in numerous diseases, most notably cancer. Inhibiting specific kinases has become a cornerstone of targeted cancer therapy.

The 2-aminopyridine scaffold, present in 2-Amino-5-bromopyridin-3-ol, is a well-established pharmacophore that can effectively interact with the hinge region of kinase active sites, a binding mode critical for potent inhibition. Our high-purity 2-Amino-5-bromopyridin-3-ol serves as a foundational intermediate in the construction of molecules designed to target kinases like ALK (Anaplastic Lymphoma Kinase) and c-MET. By strategically modifying the bromine and hydroxyl positions, medicinal chemists can fine-tune inhibitor potency, selectivity, and pharmacokinetic properties. As a reliable manufacturer, we ensure that researchers have access to this vital building block to advance their work in oncological drug discovery.

Beyond Kinase Inhibitors: Diverse Applications

While its role in kinase inhibitor synthesis is prominent, the utility of 2-Amino-5-bromopyridin-3-ol extends far beyond. Its versatility as an organic synthesis intermediate makes it valuable for:

  • Developing novel heterocyclic compounds: The compound is a gateway to synthesizing a vast array of heterocyclic structures with potential biological activities.
  • Drug discovery for various therapeutic areas: Beyond oncology, derivatives are explored for applications in treating neurodegenerative diseases, inflammatory conditions, and more.
  • Fragment-based drug design: Its well-defined structure and reactive handles make it an excellent starting point for building larger, more complex drug candidates.

As a leading supplier in China, we are committed to providing researchers worldwide with this essential compound. We understand the need for consistent quality and competitive pricing, especially when sourcing materials for large-scale synthesis or ongoing research projects. When you search for a '2-amino-5-bromopyridin-3-ol manufacturer' or 'buy 2-amino-5-bromopyridin-3-ol price', consider partnering with us for a reliable and high-quality supply chain solution.

To learn more about how our 2-Amino-5-bromopyridin-3-ol can support your research or to request a quote for bulk purchase, please contact us. We are dedicated to empowering scientific innovation through exceptional chemical sourcing.