In the intricate world of pharmaceutical manufacturing and drug discovery, the availability of high-quality chemical intermediates is paramount. Among these essential building blocks, 2-Bromo-5-hydroxybenzaldehyde stands out due to its significant role in synthesizing a range of therapeutic compounds. This article delves into the properties, synthesis pathways, and critical applications of 2-Bromo-5-hydroxybenzaldehyde, highlighting its importance for researchers and manufacturers.

2-Bromo-5-hydroxybenzaldehyde, identified by its CAS number 2973-80-0, is a fine chemical intermediate characterized by its appearance as a white to brown powder. With a melting point typically ranging between 130-135°C, it possesses a distinct chemical structure that makes it an ideal precursor for more complex molecules. Its molecular formula, C7H5BrO2, and molecular weight of approximately 201.02 g/mol, provide the foundational elements for sophisticated organic synthesis.

One of the most prominent applications of 2-Bromo-5-hydroxybenzaldehyde is its use as a key intermediate in the synthesis of Crisaborole. Crisaborole is an active pharmaceutical ingredient (API) known for its efficacy in treating atopic dermatitis, a common inflammatory skin condition. The development of Crisaborole highlights the significance of reliable access to intermediates like 2-Bromo-5-hydroxybenzaldehyde for bringing life-changing treatments to market.

Beyond Crisaborole, this versatile compound serves as a valuable reactant in the preparation of various other pharmaceutical agents. Its structure facilitates the development of molecules that can inhibit phosphodiesterase 4 (PDE4) and Bcl-XL, proteins implicated in inflammation and cancer cell growth respectively. This makes 2-Bromo-5-hydroxybenzaldehyde a crucial component for researchers working on anti-inflammatory drugs and novel cancer therapies.

The synthesis of 2-Bromo-5-hydroxybenzaldehyde often involves careful bromination of precursor compounds. While various synthetic routes exist, ensuring high purity and consistent yield is essential for its industrial application. Manufacturers in China, like NINGBO INNO PHARMCHEM CO.,LTD., play a vital role in supplying this chemical to the global market, adhering to stringent quality control measures.

For those involved in pharmaceutical organic synthesis, understanding the properties and sourcing channels for intermediates like 2-Bromo-5-hydroxybenzaldehyde is key to efficient and successful drug development. The ability to buy or purchase this compound from reputable suppliers ensures that research projects and manufacturing processes can proceed without interruption, ultimately contributing to the advancement of healthcare.

In summary, 2-Bromo-5-hydroxybenzaldehyde is more than just a chemical compound; it is an enabler of pharmaceutical innovation. Its role as a crucial intermediate in the synthesis of important drugs underscores its value in the chemical and pharmaceutical industries, making it a compound of considerable interest for R&D and manufacturing.