In the complex world of pharmaceutical manufacturing, the quality and availability of key intermediates are paramount. Among these vital compounds is 2-Hydroxybenzoyl Chloride, identified by its CAS number 1441-87-8. This versatile organic compound serves as a critical building block for a wide array of Active Pharmaceutical Ingredients (APIs), making it a cornerstone in the development of life-saving medications. Understanding its properties, applications, and how to effectively source it is essential for any B2B professional in the pharmaceutical and fine chemical sectors.

What is 2-Hydroxybenzoyl Chloride?

2-Hydroxybenzoyl Chloride, also known by its synonym salicyloyl chloride, is characterized by its molecular formula C7H5ClO2 and a molecular weight of approximately 156.57 g/mol. It features a benzene ring with a hydroxyl group positioned ortho to an acyl chloride group. This specific arrangement of functional groups imparts significant reactivity, particularly in acylation reactions. Its physical properties, such as a melting point around 19°C and a boiling point of approximately 217.69°C, classify it typically as a colorless to pale yellow liquid, though it can also appear as a low-melting solid under certain conditions. Due to the reactive nature of the acyl chloride moiety, it demands careful handling and storage under anhydrous conditions to prevent decomposition and maintain its integrity.

Key Applications in Pharmaceutical Manufacturing

The primary utility of 2-Hydroxybenzoyl Chloride lies in its role as a pivotal pharmaceutical intermediate. Its reactive acyl chloride group readily participates in reactions with nucleophiles, such as amines and alcohols, to form amide and ester linkages, respectively. This capability is extensively utilized in the multi-step synthesis of complex APIs. For instance, it has been noted for its use in the synthesis of certain diuretic agents, contributing to the development of therapies for cardiovascular conditions. Furthermore, its structure makes it an ideal precursor for introducing the salicyloyl moiety into target molecules, a feature valuable in designing compounds with specific biological activities.

The Importance of Reliable Sourcing: Manufacturer vs. Trader

For procurement managers and R&D scientists, sourcing high-quality 2-Hydroxybenzoyl Chloride at a competitive price is a strategic decision. When looking to buy this essential chemical, it is vital to partner with a reputable manufacturer, especially one located in China, which has become a global hub for chemical production. A direct manufacturer can often provide better quality control, consistent supply, and more favorable pricing compared to a trading company. When selecting a supplier, consider factors such as purity levels, adherence to international quality standards, production capacity, and their ability to provide technical support and timely delivery. Getting a precise quote from a trusted manufacturer is the first step to securing your supply chain.

Global Demand and Future Trends

The demand for intermediates like 2-Hydroxybenzoyl Chloride is intrinsically linked to the growth of the global pharmaceutical industry. As research and development in drug discovery continue to accelerate, the need for specialized chemical building blocks remains high. Trends indicate an increasing focus on high-purity intermediates to meet the rigorous requirements of modern pharmaceutical production. Therefore, identifying and establishing long-term relationships with reliable manufacturers and suppliers for compounds such as CAS 1441-87-8 will be crucial for companies aiming to innovate and expand their product portfolios. If you are seeking to purchase this compound, exploring options from leading Chinese chemical manufacturers can offer significant advantages in terms of both cost and accessibility.

In conclusion, 2-Hydroxybenzoyl Chloride is more than just a chemical compound; it is an enabler of pharmaceutical progress. By understanding its chemical characteristics and strategic importance, B2B professionals can make informed decisions regarding its procurement, ensuring the success of their drug development and manufacturing initiatives. For inquiries about buying or obtaining a quote for this vital intermediate, engaging with experienced chemical suppliers in China is highly recommended.