The field of targeted protein degradation, particularly through Proteolysis Targeting Chimeras (PROTACs), has revolutionized drug discovery. At the heart of many PROTAC molecules lies a linker, a crucial component that connects the protein of interest (POI) binder to the E3 ligase binder. Among the widely used linkers is Amino-PEG3, chemically known as 2-[2-(2-Aminoethoxy)ethoxy]ethanol (CAS 6338-55-2). This article delves into the significance of this compound for researchers and procurement managers looking to buy high-quality chemical intermediates from a reliable manufacturer.

Amino-PEG3, with its defined triethylene glycol spacer and terminal amine group, offers several advantages. The polyethylene glycol (PEG) chain imparts water solubility and can help reduce steric hindrance, improving the overall efficiency and bioavailability of the PROTAC. The amine functionality is highly reactive, allowing for straightforward conjugation to other molecular components via amide bond formation or other amine-reactive chemistries. As a specialized chemical intermediate, sourcing this material from a reputable supplier in China like NINGBO INNO PHARMCHEM CO.,LTD. ensures consistent purity and availability for your research and development projects.

The synthesis of PROTACs often requires building blocks that are reliable and well-characterized. Amino-PEG3 (CAS 6338-55-2) fits this requirement perfectly. Its bifunctional nature, with the amine on one end and a readily derivatizable hydroxyl group on the other (though often the amine is the primary point of attachment in PROTACs), makes it a versatile tool. For companies seeking to purchase this compound, understanding its role as a PEG linker is key. It's not just a chemical; it's an enabler of next-generation therapeutics.

When considering where to buy Amino-PEG3, look for suppliers who can provide detailed technical specifications, Certificates of Analysis (CoA), and demonstrate robust quality control processes. NINGBO INNO PHARMCHEM CO.,LTD. stands out as a prime manufacturer, offering this essential PROTAC linker in bulk quantities. Our commitment to quality and customer satisfaction ensures that you receive a product that meets your demanding research standards. Engage with us to secure your supply and accelerate your PROTAC development pipeline.