The field of peptide synthesis is continuously evolving, demanding increasingly sophisticated building blocks to create novel therapeutic peptides and research tools. At the heart of many such syntheses lies Boc-L-Aspartic Acid 4-tert-butyl Ester (CAS 1676-90-0), a protected amino acid derivative that plays a crucial role in achieving precise and efficient chain elongation.

Understanding the Structure and Function of Boc-L-Aspartic Acid 4-tert-butyl Ester

Boc-L-Aspartic Acid 4-tert-butyl Ester, with the molecular formula C13H23NO6, features two key protecting groups: the tert-butyloxycarbonyl (Boc) group on the alpha-amino functionality and a tert-butyl ester on the beta-carboxyl group of aspartic acid. These protecting groups are essential for solid-phase or solution-phase peptide synthesis. The Boc group is acid-labile, allowing for its selective removal under mild acidic conditions, thus freeing the alpha-amino group for the next coupling step. Simultaneously, the tert-butyl ester protects the side-chain carboxyl group of aspartic acid, preventing unwanted side reactions during peptide bond formation.

Why Purity Matters in Peptide Synthesis Reagents

The success of any peptide synthesis hinges on the purity of its starting materials. For Boc-L-Aspartic Acid 4-tert-butyl Ester, a minimum purity of 98-99% is highly desirable. Even trace impurities can lead to the formation of deletion sequences, truncated peptides, or modified peptides, which can significantly complicate purification and reduce the yield of the desired product. When sourcing this chemical, always request a detailed Certificate of Analysis (CoA) from the supplier.

Sourcing Strategies for Researchers and Manufacturers

Researchers and peptide manufacturers often look for reliable suppliers who can provide consistent quality and quantity. Chinese manufacturers specializing in fine chemicals and amino acid derivatives have become a primary source for these critical reagents. When you consider to buy Boc-L-Aspartic Acid 4-tert-butyl Ester, consider the following:

  • Specialized Manufacturers: Focus on suppliers with a demonstrated expertise in amino acid chemistry and peptide reagents.
  • Bulk vs. Research Quantities: Depending on your needs, you can source it in gram quantities for research or in kilogram batches for larger-scale synthesis. The price per gram typically decreases with larger order volumes.
  • Global Shipping Options: Ensure the manufacturer offers reliable international shipping, understanding the Incoterms and customs procedures involved.

The availability of high-quality Boc-L-Aspartic Acid 4-tert-butyl Ester (CAS 1676-90-0) from trusted manufacturers enables scientists to push the boundaries of peptide research and development, leading to new discoveries and therapeutic applications. By carefully selecting your suppliers, you can ensure the integrity and success of your peptide synthesis projects.