In the intricate world of pharmaceutical manufacturing, the precision and purity of intermediates are paramount. Among these, chiral intermediates play an increasingly significant role, particularly in the development of drugs that exhibit stereospecific activity. One such critical compound is (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one, identified by CAS number 189028-95-3.

This particular oxazolidinone derivative serves as a cornerstone in the synthesis of Ezetimibe, a widely prescribed medication for lowering plasma cholesterol levels. Ezetimibe functions by inhibiting cholesterol absorption in the small intestine, thereby reducing the amount of cholesterol that reaches the liver. The efficacy and safety of Ezetimibe are directly linked to its specific stereochemistry, making the precise synthesis of its intermediates, such as the compound in question, absolutely essential. Any deviation in chirality can lead to reduced efficacy or even the introduction of unwanted side effects.

Procuring high-quality chiral intermediates like CAS 189028-95-3 requires partnering with reputable manufacturers and suppliers. Buyers often seek suppliers in China due to the competitive pricing and established manufacturing capabilities. When looking to buy this pharmaceutical intermediate, considerations such as purity levels (typically 99% or higher), consistent batch-to-batch quality, and a stable supply chain are critical. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in sourcing and supplying such advanced intermediates, ensuring that researchers and pharmaceutical companies have access to the materials they need for successful drug development.

The synthesis of (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one itself is a multi-step process, often involving sophisticated chemical reactions to ensure the correct stereochemical configuration. Understanding these synthetic routes and the physical properties of the compound, such as its white powder appearance and solubility in certain organic solvents, is key for effective process development and quality control. For procurement managers and R&D scientists, securing a reliable manufacturer that can consistently deliver this intermediate is crucial for maintaining production schedules and product quality.

Furthermore, the market for pharmaceutical intermediates is dynamic. Staying informed about reliable suppliers, pricing trends, and regulatory requirements is vital. When seeking to purchase this specific intermediate, performing due diligence on potential suppliers, requesting samples, and reviewing Certificates of Analysis (CoA) are standard practices. Engaging with established suppliers ensures not only the quality of the product but also the necessary technical support and regulatory compliance information. For companies operating in the pharmaceutical sector, securing a dependable supply of critical chiral building blocks like CAS 189028-95-3 is a strategic imperative for bringing life-saving medications to market.