In the dynamic field of biochemical research and drug discovery, the precise synthesis of peptides is paramount. Among the diverse array of building blocks available,Fmoc-3-L-Ala(2-thienyl)-OH (CAS 130309-35-2) stands out for its unique structural contribution. This article delves into the significance of this specialized Fmoc-amino acid derivative and highlights why sourcing it from a reputable manufacturer is crucial for successful project outcomes.

Understanding Fmoc-3-L-Ala(2-thienyl)-OH

Fmoc-3-L-Ala(2-thienyl)-OH is an N-alpha-Fmoc protected derivative of alanine, featuring a thiophene ring in its side chain. The Fmoc (9-fluorenylmethyloxycarbonyl) protecting group is a cornerstone of solid-phase peptide synthesis (SPPS), prized for its base-lability, allowing for orthogonal deprotection strategies. The incorporation of the thiophene moiety introduces novel chemical and biological properties, making it an 'unusual amino acid' that can imbue synthesized peptides with enhanced stability, altered binding affinities, or unique pharmacological effects. Its CAS number, 130309-35-2, is a key identifier for researchers seeking this specific compound.

Applications in Peptide Synthesis and Beyond

The primary application of Fmoc-3-L-Ala(2-thienyl)-OH is in the construction of complex peptide sequences via SPPS. Researchers and pharmaceutical companies utilize this building block to:

  • Synthesize novel peptide therapeutics: The thiophene ring can influence a peptide's interaction with biological targets, potentially leading to more potent or selective drug candidates.
  • Develop peptidomimetics: Its unique structure can be leveraged to design molecules that mimic the function of natural peptides but with improved pharmacokinetic properties.
  • Investigate protein-peptide interactions: Incorporating this unnatural amino acid can help elucidate the roles of specific residues in molecular recognition events.
  • Create peptide-based probes for diagnostics and research.

As a key pharmaceutical intermediate, its availability is critical for the early stages of drug development. For those looking to buy Fmoc-3-L-Ala(2-thienyl)-OH, understanding its role is the first step.

Why Choose a Reliable Fmoc-Amino Acid Supplier?

The success of any peptide synthesis endeavor hinges on the quality and reliability of the starting materials. When you need to purchase Fmoc-3-L-Ala(2-thienyl)-OH, partnering with a trusted supplier is not just about obtaining the chemical; it's about ensuring:

  • Purity: Contaminants in unusual amino acids can lead to failed synthesis, impure products, and wasted resources. A reputable manufacturer guarantees high purity levels, often specified by an accompanying Certificate of Analysis.
  • Consistency: Batch-to-batch consistency is vital for reproducible research. A dedicated supplier ensures that each order of CAS 130309-35-2 meets stringent specifications.
  • Availability: For ongoing research or production, a reliable supply chain is essential. Working with a manufacturer that maintains stock or offers robust custom synthesis services ensures your project timelines are met.
  • Technical Support: Experienced suppliers can offer valuable insights into product handling, storage, and application, especially for less common building blocks like this one.

When sourcing for your laboratory or production facility, always inquire about the manufacturer's reputation, quality control processes, and their commitment to providing competitive pricing for bulk purchases. For researchers in China and globally, finding a dependable Fmoc-amino acid supplier is a strategic advantage.

In conclusion, Fmoc-3-L-Ala(2-thienyl)-OH is more than just a chemical; it's an enabler of innovation in peptide science. By understanding its utility and prioritizing quality sourcing, researchers can confidently advance their groundbreaking work. If you are looking for this crucial component, reach out to our team to discuss your needs and get a competitive quote. We are your trusted partner for advanced peptide synthesis reagents.