The landscape of pharmaceutical development is constantly evolving, driven by the need for more effective and targeted therapies. At the heart of this innovation are advanced chemical building blocks, and L-2-Fluorophenylalanine has emerged as a compound of significant interest. This article explores the role of L-2-Fluorophenylalanine as a crucial pharmaceutical intermediate, detailing its chemical attributes and why manufacturers and R&D scientists alike value its inclusion in synthesis pathways.

L-2-Fluorophenylalanine, scientifically known as (S)-2-amino-3-(2-fluorophenyl)propanoic acid, is a chiral non-proteinogenic amino acid. Its CAS number is 19883-78-4. Unlike the 20 standard amino acids found in proteins, L-2-Fluorophenylalanine is synthetically derived and offers unique properties due to the presence of a fluorine atom on its phenyl ring. This structural feature is key to its utility in medicinal chemistry and drug design.

The incorporation of fluorine into organic molecules, a process known as fluorination, can profoundly alter their physicochemical and biological properties. For pharmaceutical intermediates, this means that L-2-Fluorophenylalanine can impart enhanced lipophilicity, leading to improved membrane permeability. It can also influence the molecule's electronic properties, potentially increasing binding affinity to target receptors or enzymes. Furthermore, the carbon-fluorine bond is one of the strongest single bonds in organic chemistry, which can contribute to increased metabolic stability, thereby prolonging the drug's half-life in the body.

Manufacturers, such as NINGBO INNO PHARMCHEM CO.,LTD., who specialize in producing high-purity chemical intermediates, recognize the demand for L-2-Fluorophenylalanine. Its presentation as a white to off-white crystalline powder with a purity typically exceeding 97% makes it an attractive starting material for complex multi-step syntheses. The chiral nature of this amino acid is also critical; the specific (S)-enantiomer is often required for biological activity, and reliable suppliers ensure stereochemical purity.

The applications for L-2-Fluorophenylalanine as a pharmaceutical intermediate are diverse. It is frequently used in the synthesis of peptide analogues and peptidomimetics, where it can introduce resistance to enzymatic degradation or alter receptor binding profiles. Its utility extends to the development of drugs targeting the central nervous system (CNS), where its lipophilicity can aid in crossing the blood-brain barrier. Researchers investigating novel treatments for neurological disorders often seek to buy this compound as a key component in their synthetic strategies.

For companies in the pharmaceutical industry, securing a consistent supply of high-quality L-2-Fluorophenylalanine is essential. Direct purchase from manufacturers provides assurance of quality and can offer cost advantages, especially for bulk requirements. When you need to buy CAS 19883-78-4, partnering with a reputable supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures you receive a product that meets the rigorous standards demanded by pharmaceutical research and manufacturing. We are a dedicated supplier ready to fulfill your requirements.