In the intricate world of pharmaceutical manufacturing, the quality and reliability of intermediate chemicals are paramount. For those involved in producing life-saving medications, understanding the specifics of each component is crucial. One such vital chemical intermediate is L-Valine benzyl ester p-toluenesulfonate salt (CAS 16652-76-9). This compound plays a pivotal role, particularly in the synthesis of Valsartan, a widely prescribed medication for hypertension and heart failure.

What is L-Valine Benzyl Ester p-Toluenesulfonate Salt?

L-Valine benzyl ester p-toluenesulfonate salt is a derivative of the essential amino acid L-valine. It is characterized by its benzyl ester functional group and its stabilization as a p-toluenesulfonate (tosylate) salt. This specific salt form enhances its stability and ease of handling, making it an ideal choice for industrial applications. The compound typically appears as a white crystal with a high purity level, often exceeding 99.0%, which is critical for pharmaceutical synthesis.

The Crucial Role in Valsartan Synthesis

Valsartan, an Angiotensin II Receptor Blocker (ARB), is a cornerstone in managing cardiovascular diseases. The synthesis of Valsartan involves multiple complex steps, and L-Valine benzyl ester p-toluenesulfonate salt serves as a key chiral building block. Its enantiopure nature ensures the correct stereochemistry of the final drug product, which is vital for therapeutic efficacy and safety. Pharmaceutical companies and contract manufacturers often look to buy high-purity intermediates like this from trusted sources to guarantee the quality of their Active Pharmaceutical Ingredients (APIs).

Sourcing and Quality Considerations for Procurement Managers

For procurement managers and purchasing professionals in the pharmaceutical industry, sourcing L-Valine benzyl ester p-toluenesulfonate salt requires careful consideration. Key factors include:

  • Purity: A minimum purity of 99.0% is usually non-negotiable for pharmaceutical intermediates to ensure the quality and safety of the final drug.
  • Supplier Reliability: Partnering with a reputable manufacturer and supplier, especially one based in China known for its chemical manufacturing capabilities, is essential for a stable supply chain.
  • Pricing: Competitive pricing is always a consideration, but it should never come at the expense of quality. Understanding the price range and negotiating for bulk orders can lead to significant cost savings.
  • Documentation: Availability of certificates of analysis (CoA), Material Safety Data Sheets (MSDS), and other relevant regulatory documents is crucial for compliance.

Why Choose a Dedicated Manufacturer?

Opting for a dedicated manufacturer or a specialized chemical supplier for L-Valine benzyl ester p-toluenesulfonate salt offers distinct advantages. These companies often have robust quality control systems, advanced synthesis technologies, and the capacity for large-scale production. They can provide not only competitive pricing but also consistent product quality and reliable delivery schedules. For instance, engaging with a supplier in China that specializes in pharmaceutical intermediates can offer a strategic advantage in terms of both cost and accessibility.

Getting a Quote and Moving Forward

If your organization requires L-Valine benzyl ester p-toluenesulfonate salt for Valsartan synthesis or other peptide chemistry applications, reaching out for a detailed quote is the next logical step. By clearly stating your purity requirements, quantity needs, and desired delivery timelines, you can work with a reliable chemical provider to secure this essential pharmaceutical intermediate. This proactive approach ensures your research and development efforts, as well as your manufacturing operations, proceed smoothly and efficiently.