The development of reliable experimental models is fundamental to understanding complex diseases and testing potential treatments. In the field of oncology, particularly for gastric carcinoma, 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG), CAS 70-25-7, plays a pivotal role. This potent chemical mutagen, supplied by dedicated manufacturers and distributors, is instrumental in creating animal models that closely mimic human gastric cancer, facilitating groundbreaking research. For scientists and procurement specialists seeking this compound, understanding its application in model creation is key.

MNNG functions as an alkylating agent, directly interacting with cellular DNA to induce mutations. When administered to laboratory animals, these mutations can trigger uncontrolled cell growth, a hallmark of cancer. Specifically, MNNG has been extensively studied and utilized for its efficacy in inducing gastric tumors in rodents. This is achieved through various administration routes, depending on the specific research protocol, allowing scientists to study the initiation, progression, and even metastasis of gastric carcinoma in a controlled environment.

The use of MNNG in generating these models is crucial for several reasons:

  • Mechanism of Carcinogenesis: MNNG helps researchers elucidate the specific genetic and molecular pathways involved in the development of gastric cancer.
  • Preclinical Drug Testing: These induced models provide a platform for evaluating the efficacy and safety of novel anti-cancer drugs before human trials.
  • Biomarker Discovery: Studying tumors induced by MNNG can aid in identifying potential biomarkers for early diagnosis and prognosis.

For researchers or institutions looking to buy 1-Methyl-3-nitro-1-nitrosoguanidine for this purpose, partnering with a reputable 1-Methyl-3-nitro-1-nitrosoguanidine manufacturer or supplier is essential. The consistency and purity of the MNNG directly impact the reliability and reproducibility of the induced cancer models. Therefore, sourcing CAS 70-25-7 from a trusted source that provides comprehensive product documentation, such as lot-specific COAs and safety data sheets (SDS), is paramount. We are a dedicated manufacturer and supplier committed to providing high-quality MNNG to facilitate such critical research.

When inquiring about MNNG, it's important to communicate your research objectives to the 1-Methyl-3-nitro-1-nitrosoguanidine supplier. They can often provide guidance on appropriate grades and quantities. The price of this essential research chemical is influenced by purity, quantity, and market demand. By engaging with manufacturers who offer competitive pricing, research institutions can optimize their budgets while securing vital materials for their gastric carcinoma research.

In conclusion, MNNG (CAS 70-25-7) remains a cornerstone chemical for establishing vital gastric carcinoma models. Its ability to induce specific DNA damage makes it an unparalleled tool for advancing our understanding and treatment of this disease. As a leading 1-Methyl-3-nitro-1-nitrosoguanidine manufacturer, we are dedicated to supporting this vital research by providing reliable access to high-purity MNNG. Contact us to learn how you can purchase this essential compound for your research needs.