The Role of Tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate in Modern Drug Synthesis
The pharmaceutical industry constantly seeks novel molecules and efficient synthetic pathways to develop life-saving treatments. Among the vast array of chemical compounds utilized, certain intermediates stand out due to their pivotal role in the synthesis of complex drug molecules. One such compound is tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate (CAS: 877399-50-3). This chemical entity has gained significant attention as a key building block, particularly in the creation of targeted therapies like Crizotinib.
Crizotinib, known by its brand name Xalkori, is a targeted therapy used in the treatment of specific types of non-small cell lung cancer (NSCLC) that exhibit ALK or ROS1 gene alterations. The intricate structure of Crizotinib requires a reliable and high-purity precursor, and tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate fits this requirement perfectly. Its molecular structure integrates a protected piperidine ring with a bromopyrazole moiety, offering specific reactivity points that are essential for the subsequent steps in Crizotinib's complex synthesis.
From a chemical standpoint, this compound is characterized by its off-white powder appearance and a high purity level, often u226598.0%. These specifications are critical for ensuring predictable reaction outcomes and minimizing the formation of unwanted byproducts in pharmaceutical manufacturing. The tert-butyl ester group provides necessary protection for the piperidine nitrogen, allowing for selective chemical transformations elsewhere in the molecule. Meanwhile, the bromine atom on the pyrazole ring offers a handle for further functionalization, commonly through cross-coupling reactions.
As a reputable manufacturer and supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality pharmaceutical intermediates to researchers and manufacturers worldwide. Our commitment to stringent quality control ensures that each batch of tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate meets the exacting demands of drug development. By supplying this critical intermediate, we aim to support the advancement of medicinal chemistry and contribute to the creation of innovative pharmaceuticals that can significantly improve patient outcomes.
The application of this bromopyrazole derivative extends beyond Crizotinib. Its versatile structure makes it a valuable asset in general organic synthesis and medicinal chemistry for the exploration of new drug candidates targeting various diseases. Researchers often seek out such intermediates to build diverse libraries of compounds for high-throughput screening, accelerating the discovery process. The ability to buy this essential chemical intermediate directly from a trusted source like NINGBO INNO PHARMCHEM CO.,LTD. simplifies the procurement process for research institutions and pharmaceutical companies alike.
In conclusion, tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate is more than just a chemical compound; it's a cornerstone for innovation in pharmaceutical synthesis. Its high purity and specific chemical properties make it indispensable for creating advanced therapeutics, and NINGBO INNO PHARMCHEM CO.,LTD. is proud to be a reliable partner in this endeavor, offering this key intermediate to fuel the next generation of drug discovery.
Crizotinib, known by its brand name Xalkori, is a targeted therapy used in the treatment of specific types of non-small cell lung cancer (NSCLC) that exhibit ALK or ROS1 gene alterations. The intricate structure of Crizotinib requires a reliable and high-purity precursor, and tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate fits this requirement perfectly. Its molecular structure integrates a protected piperidine ring with a bromopyrazole moiety, offering specific reactivity points that are essential for the subsequent steps in Crizotinib's complex synthesis.
From a chemical standpoint, this compound is characterized by its off-white powder appearance and a high purity level, often u226598.0%. These specifications are critical for ensuring predictable reaction outcomes and minimizing the formation of unwanted byproducts in pharmaceutical manufacturing. The tert-butyl ester group provides necessary protection for the piperidine nitrogen, allowing for selective chemical transformations elsewhere in the molecule. Meanwhile, the bromine atom on the pyrazole ring offers a handle for further functionalization, commonly through cross-coupling reactions.
As a reputable manufacturer and supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality pharmaceutical intermediates to researchers and manufacturers worldwide. Our commitment to stringent quality control ensures that each batch of tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate meets the exacting demands of drug development. By supplying this critical intermediate, we aim to support the advancement of medicinal chemistry and contribute to the creation of innovative pharmaceuticals that can significantly improve patient outcomes.
The application of this bromopyrazole derivative extends beyond Crizotinib. Its versatile structure makes it a valuable asset in general organic synthesis and medicinal chemistry for the exploration of new drug candidates targeting various diseases. Researchers often seek out such intermediates to build diverse libraries of compounds for high-throughput screening, accelerating the discovery process. The ability to buy this essential chemical intermediate directly from a trusted source like NINGBO INNO PHARMCHEM CO.,LTD. simplifies the procurement process for research institutions and pharmaceutical companies alike.
In conclusion, tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate is more than just a chemical compound; it's a cornerstone for innovation in pharmaceutical synthesis. Its high purity and specific chemical properties make it indispensable for creating advanced therapeutics, and NINGBO INNO PHARMCHEM CO.,LTD. is proud to be a reliable partner in this endeavor, offering this key intermediate to fuel the next generation of drug discovery.
Perspectives & Insights
Core Pioneer 24
“By supplying this critical intermediate, we aim to support the advancement of medicinal chemistry and contribute to the creation of innovative pharmaceuticals that can significantly improve patient outcomes.”
Silicon Explorer X
“Its versatile structure makes it a valuable asset in general organic synthesis and medicinal chemistry for the exploration of new drug candidates targeting various diseases.”
Quantum Catalyst AI
“Researchers often seek out such intermediates to build diverse libraries of compounds for high-throughput screening, accelerating the discovery process.”