In the realm of organic chemistry, specific compounds emerge as linchpins for complex synthetic routes, and 3,4,5-Trifluorophenylboronic acid (CAS 143418-49-9) is a prime example. This article explores the scientific underpinnings of this vital intermediate, detailing its chemical and physical properties and illuminating its extensive applications in modern synthesis. For researchers and manufacturers, understanding these aspects is key to leveraging its full potential in their projects.

Chemically, 3,4,5-Trifluorophenylboronic acid is characterized by its trifluorinated phenyl ring attached to a boronic acid group. This structure imparts unique electronic and steric properties that are highly beneficial in organic reactions. With a molecular formula of C6H4BF3O2 and a molecular weight of approximately 175.90, it exhibits distinct characteristics such as a melting point typically in the range of 290-295 °C. Its high purity, often specified as ≥97% or ≥99.5% depending on the grade, ensures predictable and reproducible results in sensitive synthetic processes.

The primary utility of 3,4,5-Trifluorophenylboronic acid lies in its role as a coupling partner in palladium-catalyzed cross-coupling reactions, most notably the Suzuki-Miyaura reaction. This reaction is a cornerstone of modern organic synthesis, allowing for the efficient formation of carbon-carbon bonds, which is critical for constructing complex molecules. The trifluorinated nature of the phenyl ring can influence the reactivity and electronic properties of the resulting coupled products, making it a strategic choice for introducing fluorine into target structures. This is particularly advantageous in pharmaceutical research, where fluorine substitution can modulate a drug's metabolic stability, lipophilicity, and receptor binding affinity.

When considering the acquisition of this compound, professionals often look for a reliable 3,4,5-Trifluorophenylboronic acid supplier who can provide consistent quality and technical support. The ability to buy this intermediate from a reputable manufacturer ensures that it meets stringent purity requirements essential for demanding applications. Furthermore, understanding its solubility and storage conditions (e.g., storing below +30°C) is vital for maintaining its integrity and efficacy.

The applications extend beyond pharmaceuticals to agrochemicals and advanced materials, including liquid crystals and specialized polymers. Its versatility makes it a valuable component for innovation across multiple scientific disciplines. For those involved in chemical procurement, securing this essential building block from a trusted source, such as NINGBO INNO PHARMCHEM CO.,LTD., guarantees access to a high-performance intermediate that can significantly contribute to the success of your research and development endeavors.