Butyl Ethyl Malonate, scientifically known as Propanedioic acid, 1-butyl 3-ethyl ester, and carrying the CAS number 17373-84-1, is a compound of significant interest in the chemical industry, particularly for its utility as a pharmaceutical intermediate and a versatile building block in organic synthesis. A thorough understanding of its chemical and physical properties, as well as its synthesis, is essential for its effective application in industrial processes.

The molecular structure of Butyl Ethyl Malonate features a central malonic acid ester backbone with an ethyl and a butyl group attached to the ester functionalities. This structure dictates its reactivity and physical characteristics. For instance, its molecular formula is C9H16O4, and its molecular weight is approximately 188.22 g/mol. Information on its boiling point, density, and flash point is critical for safe handling and process design. As a malonic ester, it exhibits acidic alpha-hydrogens, making it amenable to a variety of alkylation and condensation reactions, which are fundamental to its role as a chemical synthesis building block.

The synthesis of Butyl Ethyl Malonate typically involves the esterification of malonic acid with ethanol and butanol, or through the alkylation of diethyl malonate with appropriate butyl halides, followed by transesterification if necessary. These synthetic routes are well-established, allowing for reliable production at industrial scales. The purity of the final product is a key determinant of its suitability for pharmaceutical applications, and manufacturers often employ rigorous purification techniques to achieve the required specifications. When seeking to purchase Butyl Ethyl Malonate, buyers will look for suppliers who can consistently deliver material meeting high purity standards, often exceeding 99%.

The applications of Propanedioic acid, 1-butyl 3-ethyl ester are diverse, primarily driven by its utility in creating more complex molecules. It serves as a precursor in the synthesis of various active pharmaceutical ingredients (APIs), agrochemicals, and specialty chemicals. The ability to introduce specific functionalities and carbon chains through its reactive sites makes it invaluable in drug discovery and development. The ongoing exploration of new malonic acid derivatives applications continues to expand its importance in the chemical sector.

In conclusion, the scientific foundation of Butyl Ethyl Malonate lies in its well-defined structure, reactivity, and accessible synthesis pathways. Its properties make it a cornerstone intermediate for numerous industrial applications, particularly in the pharmaceutical realm. By understanding and optimizing the science behind its production and use, the chemical industry can continue to leverage this valuable compound for innovation and progress.