At NINGBO INNO PHARMCHEM CO.,LTD., we understand that the foundation of effective pharmaceutical products lies in the quality and characteristics of their constituent ingredients. Copovidone VA64, a sophisticated VP/VA Copolymer (CAS 25086-89-9), is a prime example of such an ingredient, offering a unique blend of properties that make it exceptionally valuable in pharmaceutical manufacturing.

Chemically, Copovidone VA64 is a linear random copolymer of N-vinylpyrrolidone (NVP) and vinyl acetate (VA) in a mass ratio of approximately 6:4. This specific composition imparts a balance of hydrophilic and hydrophobic characteristics, which are crucial for its diverse applications. Unlike pure povidone, the vinyl acetate component reduces hygroscopicity and lowers the glass transition temperature (Tg), making VA64 more adaptable to various processing conditions and environmental factors.

One of the most significant properties of Copovidone VA64 is its excellent binding capability. It serves as a highly effective dry binder for direct compression and roller compaction, facilitating the formation of strong, durable tablets. Its plasticity allows the granules and powders to deform under pressure, reducing the likelihood of capping and lamination. The fine particle size and spherical morphology of VA64 also contribute to improved powder flow and blend uniformity, essential for consistent tablet production. The insights into copovidone VA64 pharmaceutical uses highlight these benefits in detail.

Beyond its role as a binder, Copovidone VA64 is also recognized for its capabilities as a film former and solubilizer. In tablet coatings, it forms smooth, flexible films that can enhance stability and appearance. Crucially, its ability to form amorphous solid dispersions significantly improves the solubility and bioavailability of poorly water-soluble drugs. This is achieved through techniques such as hot melt extrusion and spray drying, where the polymer matrix entraps the drug in an amorphous state, thereby increasing its dissolution rate. The exploration of copovidone VA64 applications reveals its potential in advanced drug delivery systems.

The solubility profile of Copovidone VA64 is also noteworthy. It is readily soluble in water, ethanol, and other common hydrophilic solvents, while exhibiting limited solubility in non-polar solvents. This solubility characteristic makes it adaptable for various formulation processes. NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality Copovidone VA64, ensuring its suitability for pharmaceutical applications, including meeting compendial standards like USP and EP. Understanding the full spectrum of copovidone VA64 properties empowers formulators to optimize their products.

In summary, Copovidone VA64 is a multifaceted excipient that offers significant advantages in pharmaceutical manufacturing, from tablet binding to advanced drug delivery. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying this vital component, supporting the development of safe, effective, and high-quality pharmaceutical products. The continuous research into PVP VA copolymer applications further solidifies its importance in the field.