Danofloxacin, identified by its CAS number 112398-08-0, stands as a cornerstone in modern veterinary medicine. As a third-generation fluoroquinolone antibiotic, its chemical structure and mode of action are designed for potent antimicrobial efficacy. This article delves into the science behind Danofloxacin, explaining its antibacterial mechanisms and the applications that make it an indispensable tool for veterinarians and animal health product manufacturers. For those looking to buy Danofloxacin, understanding its properties is key to appreciating its value.

Mechanism of Action: Inhibiting Bacterial DNA Gyrase

The primary mode of action for Danofloxacin, like other fluoroquinolones, involves targeting essential bacterial enzymes: DNA gyrase and topoisomerase IV. These enzymes are crucial for DNA replication, transcription, repair, and recombination in bacteria. By inhibiting DNA gyrase, Danofloxacin prevents the supercoiling of bacterial DNA, leading to DNA strand breaks and ultimately cell death. This targeted inhibition is highly effective against a broad spectrum of bacterial pathogens commonly encountered in veterinary settings. As a veterinary antibiotic, its precise action ensures targeted treatment with minimal impact on host cells when used appropriately.

Spectrum of Activity and Applications

Danofloxacin exhibits significant activity against a wide range of problematic bacteria, including:

  • Gram-negative bacteria such as E. coli, Salmonella spp., and Pasteurella spp.
  • Gram-positive bacteria like Staphylococcus spp. and Streptococcus spp.
  • Specific non-bacterial organisms like Mycoplasma spp. and Chlamydia spp.

This broad spectrum makes it a go-to choice for treating diverse infections. In veterinary practice, Danofloxacin is commonly prescribed for:

  • Respiratory Infections: Such as infectious bronchitis and pneumonia in poultry and swine.
  • Enteric Infections: Including bacterial enteritis in calves and piglets.
  • Systemic Infections: When widespread bacterial invasion occurs.

The development of resistance is a concern with any antibiotic, and understanding the PK/PD (pharmacokinetics/pharmacodynamics) of Danofloxacin is crucial for rational use. Manufacturers and researchers often seek high-purity Danofloxacin to ensure consistent and effective drug concentrations at the site of infection.

Sourcing High-Quality Danofloxacin

For businesses in the animal health sector, sourcing reliable Danofloxacin CAS 112398-08-0 is vital. As a key pharmaceutical intermediate, its quality directly impacts the efficacy and safety of the final veterinary drug product. When procuring from a Danofloxacin supplier, look for:

  • Verified Purity: Assurance of high purity (e.g., ≥ 98.0%) is essential for pharmaceutical applications.
  • Consistent Supply: A dependable manufacturer can ensure you have the quantities you need, when you need them.
  • Technical Support: Knowledgeable suppliers can provide valuable information regarding product specifications and handling.

We, as a dedicated Danofloxacin manufacturer, are proud to supply this critical antibiotic, ensuring animal health professionals have access to a reliable and high-quality product. By understanding the science behind Danofloxacin, we empower our clients to make informed decisions for their animal health solutions.