For professionals in the pharmaceutical, chemical, and nutritional industries, a deep understanding of the compounds they work with is essential. Folic Acid (CAS 59-30-3), also known as Vitamin B9 or pteroylglutamic acid, is a molecule of significant scientific and commercial importance. This article delves into the scientific underpinnings of Folic Acid, from its chemical structure and biological roles to its synthesis, providing valuable insights for B2B procurement and R&D.

Chemically, Folic Acid is a complex molecule composed of three parts: a pteridine ring, para-aminobenzoic acid (PABA), and L-glutamic acid. Its molecular formula is C19H19N7O6, with a molecular weight of approximately 441.4 g/mol. It typically appears as a yellow to orange crystalline powder and has limited solubility in water but is more soluble in alkaline solutions.

The biological significance of Folic Acid is profound. It is a precursor to tetrahydrofolate (THF), the active coenzyme form, which is indispensable for one-carbon metabolism. This metabolic pathway is critical for numerous cellular processes, including:

  • Nucleotide Synthesis: THF is essential for the de novo synthesis of purines and thymidylate, which are the building blocks of DNA and RNA.
  • Amino Acid Metabolism: It participates in the conversion of amino acids, such as serine to glycine and homocysteine to methionine. This is crucial for protein synthesis and preventing the buildup of harmful homocysteine.
  • DNA Methylation: Folic Acid derivatives are involved in methylation reactions, which play a role in gene expression and regulation.

A deficiency in Folic Acid can lead to serious health consequences, including megaloblastic anemia, impaired DNA synthesis, and, critically, neural tube defects in developing fetuses. This highlights its vital role in reproductive health and early development.

The synthesis of Folic Acid typically involves a multi-step chemical process. Historically, and still prevalent today, is the synthesis from precursors like 1,1,3-trichloroacetone, 2,4,5-triamino-6-hydroxypyrimidine, and p-aminobenzoylglutamic acid. This process, while effective, can generate significant wastewater and gaseous byproducts, necessitating careful environmental management by the manufacturer. NINGBO INNO PHARMCHEM CO.,LTD. employs advanced synthesis techniques to ensure product quality while adhering to responsible manufacturing practices.

For B2B professionals, understanding these scientific aspects is key to evaluating Folic Acid suppliers. When you inquire about buying Folic Acid, assessing the purity specifications, understanding potential impurities, and knowing the synthesis route can provide confidence in the product's suitability for your specific application. Whether for pharmaceutical formulation, nutritional supplements, or advanced research, high-quality Folic Acid is paramount.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing Folic Acid that meets rigorous scientific and quality standards. We understand the complexities of its synthesis and application and are committed to being a reliable supplier and manufacturer for your needs. Contact us to discuss your requirements and to learn more about the scientific integrity behind our Folic Acid products.