In the dynamic landscape of pharmaceutical research and development, the availability of high-quality chemical intermediates is paramount. Among these essential building blocks, 6-Amino-3,4-dihydroquinolin-2(1H)-one (CAS: 22246-13-5) stands out due to its significant versatility and proven utility in medicinal chemistry. For procurement managers and research scientists, understanding the strategic importance and sourcing reliable suppliers for such compounds is crucial for project success.

Understanding the Compound: Structure and Properties

6-Amino-3,4-dihydroquinolin-2(1H)-one, a bicyclic heterocyclic compound, features a dihydroquinolinone core functionalized with an amino group at the 6-position. Its molecular formula is C9H10N2O, with a molecular weight of approximately 162.19 g/mol. Typically appearing as a light yellow to light brown solid, this compound is characterized by its purity, often exceeding 97%, which is a critical parameter for pharmaceutical applications.

Key Applications in Pharmaceutical R&D

The significance of 6-Amino-3,4-dihydroquinolin-2(1H)-one lies in its broad applicability as a synthetic intermediate. It serves as a foundational scaffold for developing novel therapeutic agents, with research highlighting its potential in several key areas:

  • Anticancer Agents: Derivatives of this compound have demonstrated efficacy in inhibiting cancer cell proliferation and targeting specific pathways involved in disease progression. Its structure is being actively explored for developing new oncology treatments.
  • Antimicrobial Compounds: Studies have indicated that this compound and its derivatives possess notable antimicrobial activity against various bacterial and fungal strains. This makes it a valuable intermediate for the synthesis of new anti-infective agents.
  • Neuropharmacology: The compound's scaffold is also being investigated for its affinity with dopamine receptors, suggesting potential applications in neurological disorders.
  • General Organic Synthesis: Beyond specific therapeutic areas, its reactive functional groups make it an indispensable tool for organic chemists engaged in complex synthesis projects, enabling the creation of diverse molecular structures.

Synthetic Routes and Quality Assurance

The synthesis of 6-Amino-3,4-dihydroquinolin-2(1H)-one typically involves multi-step chemical processes, often starting from nitro-substituted precursors. Key reactions can include nitro reduction via catalytic hydrogenation (e.g., Pd/C) or chemical reduction, followed by further functionalization. For procurement managers, ensuring the purity and consistency of this intermediate is paramount. Working with a reputable manufacturer that adheres to stringent quality control measures is essential. This includes thorough characterization using techniques like NMR and mass spectrometry to validate the compound's identity and purity.

Why Partner with a Reliable Manufacturer?

For B2B clients, especially those in the pharmaceutical sector, sourcing chemical intermediates involves more than just finding the lowest price. Reliability, consistent quality, and robust supply chain management are critical. A trusted manufacturer can offer:

  • Guaranteed Purity: Ensuring that the intermediate meets or exceeds the required purity specifications (e.g., 97% min).
  • Scalability: The ability to supply quantities ranging from grams for research to kilograms or tons for commercial production.
  • Technical Support: Access to expert knowledge regarding synthesis, handling, and applications.
  • Regulatory Compliance: Adherence to international quality and safety standards.

When you are looking to buy 6-Amino-3,4-dihydroquinolin-2(1H)-one for your pharmaceutical development projects, partnering with an established manufacturer and supplier in China like ours provides a distinct advantage. We understand the critical needs of the B2B market and are committed to delivering excellence in both product quality and customer service. For the best price of 6-Amino-3,4-dihydroquinolin-2(1H)-one that ensures research integrity and timely project completion, consider your trusted chemical sourcing partner.