Tos-PEG4-t-butyl Ester: A Key Chemical Intermediate for Advancing PROTAC Technology
The landscape of pharmaceutical research is constantly evolving, with targeted protein degradation (PROTAC) emerging as a revolutionary modality. PROTACs harness the cell's natural ubiquitin-proteasome system to selectively degrade disease-causing proteins. Central to the construction of these complex molecules are chemical intermediates, and among them, Tos-PEG4-t-butyl ester plays a pivotal role.
Tos-PEG4-t-butyl ester, identified by its CAS number 217817-01-1, is a PEG-based linker that serves as an indispensable building block in PROTAC synthesis. Its chemical structure is meticulously designed to facilitate the conjugation of two distinct ligands: one targeting a protein of interest and the other recruiting an E3 ubiquitin ligase. The PEG chain provides crucial flexibility and solubility, while the tosyl group offers a reactive handle for nucleophilic substitution, and the tert-butyl ester acts as a readily removable protecting group.
The significance of Tos-PEG4-t-butyl ester as a chemical intermediate cannot be overstated. It enables chemists to efficiently synthesize PROTAC molecules with specific linker lengths and functionalities, allowing for fine-tuning of their pharmacological properties. For instance, its use in the synthesis of BI-3663, a highly selective PTK2/FAK PROTAC, highlights its capability to contribute to the development of molecules with potent protein degradation activity. BI-3663, by leveraging cereblon ligands, effectively targets E3 ligases to degrade PTK2 with a low IC50 of 18 nM.
Researchers and pharmaceutical companies often seek reliable suppliers of high-quality chemical intermediates to ensure the success of their drug development programs. Tos-PEG4-t-butyl ester, available from NINGBO INNO PHARMCHEM CO.,LTD., is a testament to the critical role that well-characterized intermediates play in accelerating the discovery and development of novel therapeutics. The precise chemical properties of this linker directly impact the efficacy and specificity of the resulting PROTACs, making its quality and availability paramount.
As the field of PROTAC technology continues to mature, the demand for specialized chemical intermediates like Tos-PEG4-t-butyl ester will undoubtedly grow. Its contribution to the synthesis of molecules that can selectively eliminate disease-associated proteins positions it as a key enabler of future precision medicines. Leveraging such intermediates is fundamental to pushing the boundaries of what is possible in targeted therapy.
Tos-PEG4-t-butyl ester, identified by its CAS number 217817-01-1, is a PEG-based linker that serves as an indispensable building block in PROTAC synthesis. Its chemical structure is meticulously designed to facilitate the conjugation of two distinct ligands: one targeting a protein of interest and the other recruiting an E3 ubiquitin ligase. The PEG chain provides crucial flexibility and solubility, while the tosyl group offers a reactive handle for nucleophilic substitution, and the tert-butyl ester acts as a readily removable protecting group.
The significance of Tos-PEG4-t-butyl ester as a chemical intermediate cannot be overstated. It enables chemists to efficiently synthesize PROTAC molecules with specific linker lengths and functionalities, allowing for fine-tuning of their pharmacological properties. For instance, its use in the synthesis of BI-3663, a highly selective PTK2/FAK PROTAC, highlights its capability to contribute to the development of molecules with potent protein degradation activity. BI-3663, by leveraging cereblon ligands, effectively targets E3 ligases to degrade PTK2 with a low IC50 of 18 nM.
Researchers and pharmaceutical companies often seek reliable suppliers of high-quality chemical intermediates to ensure the success of their drug development programs. Tos-PEG4-t-butyl ester, available from NINGBO INNO PHARMCHEM CO.,LTD., is a testament to the critical role that well-characterized intermediates play in accelerating the discovery and development of novel therapeutics. The precise chemical properties of this linker directly impact the efficacy and specificity of the resulting PROTACs, making its quality and availability paramount.
As the field of PROTAC technology continues to mature, the demand for specialized chemical intermediates like Tos-PEG4-t-butyl ester will undoubtedly grow. Its contribution to the synthesis of molecules that can selectively eliminate disease-associated proteins positions it as a key enabler of future precision medicines. Leveraging such intermediates is fundamental to pushing the boundaries of what is possible in targeted therapy.
Perspectives & Insights
Bio Analyst 88
“PROTACs harness the cell's natural ubiquitin-proteasome system to selectively degrade disease-causing proteins.”
Nano Seeker Pro
“Central to the construction of these complex molecules are chemical intermediates, and among them, Tos-PEG4-t-butyl ester plays a pivotal role.”
Data Reader 7
“Tos-PEG4-t-butyl ester, identified by its CAS number 217817-01-1, is a PEG-based linker that serves as an indispensable building block in PROTAC synthesis.”