Trifluoroacetyl Chloride (CAS: 354-32-5) is a compound of significant interest within the chemical industry, primarily serving as a reactive intermediate in various synthetic processes. Its chemical structure, featuring an acyl chloride group attached to a trifluoromethyl group, endows it with high reactivity, making it a valuable reagent for introducing specific functionalities into organic molecules.

Physically, Trifluoroacetyl Chloride is a colorless gas that fumes in moist air. It has a very low boiling point, approximately -27 °C, and a melting point of -146 °C. This gaseous state at standard temperature and pressure, combined with its corrosive and irritant nature, means that it requires specialized containment and handling procedures. Safety precautions are paramount when working with this compound, including the use of appropriate personal protective equipment (PPE) and ensuring adequate ventilation or closed systems. Those intending to buy Trifluoroacetyl Chloride should always consult its Material Safety Data Sheet (MSDS) for comprehensive handling guidelines.

Chemically, Trifluoroacetyl Chloride is a potent acylating agent. It reacts readily with water to produce trifluoroacetic acid and hydrogen chloride gas. This vigorous reaction with protic nucleophiles like water, alcohols, and amines is a hallmark of its reactivity. The formation of esters from alcohols and amides from amines are key transformations facilitated by Trifluoroacetyl Chloride, making it a sought-after intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Its specific use in the synthesis of Ibrutinib exemplifies its importance in the pharmaceutical supply chain.

For businesses seeking to source this compound, identifying a reliable trifluoroacetyl chloride manufacturer in China or other regions is a critical step. The availability of high-purity material is essential for consistent results in synthesis. Understanding the trifluoroacetyl chloride price and supplier landscape allows for strategic procurement decisions. When evaluating options, consider not only the cost but also the supplier's reputation for quality, consistency, and technical support. It's also beneficial to have a clear understanding of the CAS 354-32-5 chemical properties to ensure it meets your specific application requirements.

In summary, Trifluoroacetyl Chloride is a powerful chemical intermediate with a wide range of applications. Its demanding handling requirements are offset by its significant synthetic utility, making it an indispensable component in many chemical manufacturing processes. Careful sourcing and adherence to safety protocols are key to leveraging its full potential.