The expansion and maintenance of neural stem cells (NSCs) are tightly regulated processes, heavily influenced by the cell's metabolic state. Tauroursodeoxycholic Acid (TUDCA) has emerged as a compelling compound capable of modulating these metabolic processes to enhance NSC expansion and proliferation. This article explores TUDCA's role as a metabolic regulator in this context.

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TUDCA's metabolic regulatory functions are diverse. It influences both lipid and glucose metabolism in NSCs, creating an environment conducive to cell proliferation. In lipid metabolism, TUDCA's downregulation of LCAD, an enzyme crucial for fatty acid beta-oxidation, shifts the cell's energy preference towards de novo lipogenesis. This promotes the synthesis of essential lipids required for the formation of new cell membranes during division, thereby supporting NSC expansion.

Beyond lipid pathways, TUDCA also impacts glucose metabolism. By increasing the levels of the pyruvate dehydrogenase E1-α subunit (PDHE1-α), it enhances the conversion of pyruvate to acetyl-CoA. This critical step ensures a robust supply of cellular energy, supporting the high metabolic demands of proliferating NSCs. This dual action on both lipid and glucose metabolism makes TUDCA a powerful regulator for NSC expansion.

The implications for pharmaceutical development are substantial. Enhancing NSC expansion is a key goal for therapies targeting brain repair and neurodegenerative diseases. TUDCA's ability to orchestrate these metabolic shifts positions it as a valuable agent in these therapeutic strategies. Researchers looking to purchase TUDCA for their studies can rely on our quality and expertise.

We are a trusted supplier for your research needs, providing TUDCA that meets stringent quality standards. For laboratories focused on neurobiology, stem cell research, or drug discovery, TUDCA offers a unique opportunity to explore and harness metabolic regulation for therapeutic benefit. We invite you to inquire about our product, including pricing for bulk orders. Partner with us to source essential research chemicals from a dependable manufacturer in China.