In the dynamic world of chemical synthesis, understanding the properties and applications of key intermediates is fundamental for researchers and procurement professionals alike. 1,1-Cyclohexanediacetic Acid Monoamide, identified by its CAS number 99189-60-3, is a significant compound, particularly recognized for its role in the pharmaceutical industry. This article delves into its essential characteristics and utility, providing valuable insights for those looking to buy or utilize this chemical.

Chemical Identity and Properties

1,1-Cyclohexanediacetic Acid Monoamide is an organic compound with the molecular formula C10H17NO3 and a molecular weight of approximately 199.25 g/mol. Its structure features a cyclohexyl ring with two acetic acid groups, one of which is amidated. Synonyms often include 1,1-Cyclohexanediacetic acid monoamide and 3,3-Pentamethylene glutaramic acid, highlighting its chemical lineage.

Key physical and chemical properties include:

  • Appearance: Typically a white powder. This visual characteristic is a primary quality indicator.
  • Melting Point: Ranging between 141-146 °C (lit.), its solid state at room temperature is consistent with its powder form.
  • Boiling Point: Approximately 443.6 °C at 760 mmHg, indicating its relative thermal stability under standard atmospheric pressure.
  • Density: Around 1.1 g/cm³, providing a measure of its mass per unit volume.
  • Flash Point: Approximately 222.1 °C, suggesting a moderate flammability risk under normal handling conditions.

Specifications for Purity and Quality

For its primary applications, the purity of 1,1-Cyclohexanediacetic Acid Monoamide is critical. Standard specifications typically require an assay of ≥98.0%. Moisture content is also controlled, usually at ≤0.5%, to ensure stability and prevent degradation. These specifications are crucial for R&D scientists who need reliable reagents for their experiments and for procurement managers ensuring the quality of incoming materials.

Primary Application: Gabapentin Synthesis

The most prominent application of 1,1-Cyclohexanediacetic Acid Monoamide is its role as an intermediate in the synthesis of Gabapentin. Gabapentin is a widely used anticonvulsant medication prescribed for epilepsy and neuropathic pain. The efficiency and purity of the final Gabapentin API are directly influenced by the quality of intermediates used in its production. Therefore, sourcing high-purity 1,1-Cyclohexanediacetic Acid Monoamide from a trusted manufacturer is essential for pharmaceutical companies.

Sourcing Considerations

When looking to purchase 1,1-Cyclohexanediacetic Acid Monoamide, it is advisable to partner with specialized chemical suppliers and manufacturers. These entities can provide comprehensive technical data, ensure lot-to-lot consistency, and offer competitive pricing, especially for bulk orders. Understanding the CAS number 99189-60-3 and its associated properties empowers informed purchasing decisions, ensuring that the chosen material meets the exacting demands of pharmaceutical synthesis and research.