For chemists and material scientists, a deep understanding of chemical intermediates is fundamental to driving innovation. 1,4-Phenylenediacetonitrile (CAS 622-75-3) is one such compound, recognized for its utility as a versatile building block in various chemical industries. This article explores its key properties and diverse applications, providing insights valuable to R&D professionals and procurement specialists.

Chemically, 1,4-Phenylenediacetonitrile is an aromatic dinitrile with the molecular formula C10H8N2 and a molecular weight of approximately 156.18 g/mol. Its structure features a central benzene ring substituted at the para positions with cyanomethyl groups (-CH2CN). This arrangement imparts specific reactivity and physical characteristics. Typically, it appears as a white to light yellow crystalline powder. Its melting point is usually reported in the range of 94-96°C, indicating it is a solid at standard room temperatures. Solubility data shows it is insoluble in water but soluble in common organic solvents, a critical consideration for reaction setup and purification.

The primary utility of 1,4-Phenylenediacetonitrile lies in its role as an intermediate in organic synthesis. Its dual nitrile functionalities make it highly reactive and suitable for a variety of chemical transformations. These include nucleophilic substitutions, additions, and cyclization reactions, which are fundamental in constructing more complex organic molecules.

Key application areas where 1,4-Phenylenediacetonitrile demonstrates significant value include:

  • Pharmaceutical Synthesis: It serves as a precursor for various APIs and drug intermediates, aiding in the development of new therapeutic agents.
  • Agrochemical Development: It is used in the synthesis of pesticides and herbicides, contributing to advancements in crop protection.
  • Dyestuff Manufacturing: The compound can be incorporated into the synthesis of specialized dyes and pigments, offering unique properties.
  • Material Science: Its structure can be utilized in the development of functional materials, polymers, and COFs/MOFs ligands.

When sourcing this intermediate, it is crucial to buy from reliable manufacturers that guarantee high purity (often 97% minimum) and consistent quality. Procurement managers and research scientists should seek suppliers who provide comprehensive technical data and readily available samples to ensure project success. Understanding the chemical properties of 1,4-Phenylenediacetonitrile empowers chemists to leverage its full potential in their synthetic endeavors.