For professionals engaged in chemical synthesis and pharmaceutical development, a thorough understanding of key intermediates like 1-Acetyl-2-imidazolidinone (CAS 5391-39-9) is essential. This compound, a derivative of imidazolidinone, possesses unique chemical properties that make it a valuable reagent in various synthesis pathways, most notably in the pharmaceutical sector. This article provides a detailed look at its characteristics and applications, guiding potential buyers on its utility and sourcing.

1-Acetyl-2-imidazolidinone is characterized by its chemical formula C5H8N2O2 and a molecular weight of 128.13. It typically presents as a white crystalline powder, with a stated purity often exceeding 98% by HPLC or GC. Its melting point, commonly cited between 173-175°C or higher (up to 182-188°C in some sources), indicates a stable solid form suitable for storage and handling. Its solubility in solvents like DMSO and chloroform, though limited, is often sufficient for many synthetic procedures. When seeking to purchase this compound, these specifications are crucial for ensuring it meets your project's needs.

The primary recognized application for 1-Acetyl-2-imidazolidinone is its role as a precursor in the synthesis of pharmaceuticals, particularly the antihypertensive drug moxonidine. It is also identified as Clonidine EP Impurity A, suggesting its relevance in quality control and analytical standards within the pharmaceutical industry. Beyond these core uses, its structure suggests potential as a versatile building block in broader organic chemistry, including agrochemical and material science research, although its pharmaceutical applications remain its most prominent feature.

For businesses looking to buy 1-Acetyl-2-imidazolidinone, identifying a reliable supplier is key. Manufacturers and distributors that specialize in fine chemicals and pharmaceutical intermediates, especially those operating out of China, are often the most cost-effective sources. When making an inquiry, be prepared to specify your required quantity and purity levels, and ask for detailed technical documentation. Access to competitive pricing and dependable supply chains is vital for integrating this intermediate into your research or production pipeline.